重症急性胰腺炎患者血清PCT的动态变化及临床意义

Dynamic Changes and Clinical Significance of Serum PCT of Patients with Severe Acute Pancreatitis

目的讨论重症急性胰腺炎患者血清PCT的动态变化及临床意义。方法选取该院2015年5月—2017年5月出现重症急性胰腺炎的患者62例,根据患者是否伴有腹腔感染分为实验组(31例)以及对照组(31例),使用双抗体的夹心免疫发光法测定两组患者入院后不同时间点的PCT水平。结果实验组患者在入院第1、3、5、7天时的血清PCT水平分别为(23.46±5.62)、(24.19±8.52)、(18.62±6.55)、(15.69±8.37)g/L,对应时间点的PCT水平均明显较对照组患者高,两组差异有统计学意义(P<0.05)。经过治疗,在入院第5、7天时两组患者的血清PCT水平均较入院第1、3天时有所下降。结论重症急性胰腺炎合并腹腔感染患者血清PCT水平高于未合并腹腔感染者,通过检测PCT有利于腹腔感染的早期发现,对重症急性胰腺炎腹腔感染的防治具有重要意义。

Objective To study the dynamic changes and clinical significance of serum PCT of patients with severe acute pancreatitis. Methods 62 cases of patients with severe acute pancreatitis admitted and treated in our hospital from May 2015 to May 2017 were selected and divided into two groups with 31 cases in each according to whether the patients were with abdominal infection or not, and the PCT levels at different time periods of the two groups after admission were measured by the DBA fluorescence enzyme immunoassay. Results The serum PCT levels at 1 d, 3 d, 5 d, 7 d after admission in the experimental group were respectively（23.46 ±5.62）,（24.19 ±8.52）,（18.62 ±6.55）,（15.69 ±8.37）g/L,which were obviously higher than those in the control group, and the differences were statistically significant（P〈0.05）,after treatment, the serum PCT levels at 5 d and 7 d after admission decreased compared with those at 1 d and 3 d after admission. Conclusion The serum PCT level of patients with severe acute pancreatitis and abdominal infection is higher than that of patients without abdominal infection, and the PCT test is conducive to the early discovery of abdominal infection, which is of important significance to the prevention and cure of abdominal infection of patients with severe acute pancreatitis.