泮托拉唑对消化性溃疡合并上消化道出血患者治疗效果、不良反应及预后的影响

Effect of Pantoprazole on the Treatment Effect, Adverse Reactions and Prognosis of Patients with Peptic Ulcer and Upper Gastrointestinal Hemorrhage

目的探讨泮托拉唑对消化性溃疡合并上消化道出血患者治疗效果、不良反应及预后的影响。方法应用医学实验观察法,随机抽取该院2016年8月—2017年8月间收治的消化性溃疡合并上消化道出血患者患者100例,平均分为观察组和对照组,对照组患者50例行血凝酶单独药物治疗,观察组患者行泮托拉唑联合血凝酶,临床观察二组治疗效果、不良反应及预后。结果观察组总有效率92%明显高于对照组总有效率80%,差异有统计学意义(P<0.05);观察组预后不良反应率总率为8%明显低于对照组预后不良反应率总率20%,两组对比比较差异有统计学意义(P<0.05)。结论泮托拉唑对消化性溃疡合并上消化道出血患者的治疗,比之单独应用血凝酶治疗效果明显,能有效提升治疗效果、降低不良反应,改善患者预后生存质量,值得临床推广实施。

Objective To study the effect of pantoprazole on the treatment effect, adverse reactions and prognosis of patients with peptic ulcer and upper gastrointestinal hemorrhage. Methods 100 cases of patients with peptic ulcer and upper gastrointestinal hemorrhage admitted and treated in our hospital from August 2016 to August 2017 were selected and randomly divided into two groups with 50 cases in each, the control group were only treated with hemagglutinin,and the observation group were treated with pantoprazole and hemagglutinin, and the treatment effect, adverse reactions and prognosis of the two groups were observed. Results The total effective rate in the observation group was obviously higher than that in the control group（92% vs 80%）, and the difference was statistically significant（P〈0.05）, and the total incidence rate of adverse reactions of prognosis in the observation group was obviously lower than that in the control group（8% vs 20%）, and the difference was statistically significant（P〈0.05）. Conclusion The effect of pantoprazole and hemagglutinin in treatment of patients with peptic ulcer and upper gastrointestinal hemorrhage is more obvious than that of single hemagglutinin, which can effectively improve the treatment effect, reduce the adverse reactions and improve the prognosis survival quality, which is worth clinical promotion and application.