康复新液对颅脑损伤机械通气患者早期肠内营养的辅助作用

Helping role of Kangfuxin liquid on early enteral nutrition in craniocerebral injury patients with mechanical ventilation

目的 研究康复新液对颅脑损伤机械通气患者早期肠内营养的辅助作用及其对机械通气所产生的间接影响.方法 选择行早期肠内营养的颅脑损伤机械通气患者60例,采用随机数字表法分为治疗组和对照组各30例,两组患者均给予常规治疗和营养支持,治疗组在此基础上给予康复新液治疗.治疗前及治疗后7 d,检测两组清蛋白（ALB）、前白蛋白（PA）、总蛋白（TP）;观察两组7 d内腹胀、反流、误吸发生率;观察两组机械通气时间、ICU住院时间;比较两组28 d病死率.结果 治疗后7 d,治疗组与对照组ALB[（33.47±4.82）g/L比（30.47±4.64）g/L]、PA[（206.21±41.87）mg/L比（185.62±38.94）mg/L]、TP[（57.82±5.96）g/L比（54.47±6.17）g/L]差异均有统计学意义（t=2.456、2.338、2.139,均P〈0.05）.治疗组与对照组腹胀发生率（20.00％比53.33％）、反流发生率（16.67％比43.33％）、机械通气时间[（11.76±2.02）d比（13.02±1.96）d]、ICU住院时间[（13.74±2.31）d比（15.43±2.14）d]差异均有统计学意义（χ2=7.177、5.07,t=2.452、2.940,均P〈0.05）.两组28 d病死率差异无统计学意义（P〉0.05）.结论 康复新液对颅脑损伤机械通气患者早期肠内营养具有辅助作用,并能缩短机械通气时间.

Objective To investigate the helping role of Kangfuxin liquid on early enteral nutrition in craniocerebral injury patients with mechanical ventilation, and the indirect effect on mechanical ventilation. Methods 60 craniocerebral injury patients with mechanical ventilation and early enteral nutrition were selected, and they were randomly divided into treatment group and control group according to the digital table, 30 cases in each group. All patients were given conventional treatment and nutritional support, the patients in the treatment group were given Kangfuxin liquid. Before and 7 days after treatment, the levels of albumin （ ALB ） , pre albumin （ PA ） and totalprotein （TP） were tested. The incidence of abdominal distension, reflux and aspiration in 7 days were recorded. The time of mechanical ventilation and the stay time in ICU were recorded. The mortality rate in 28 days was recorded. Results 7 days after treatment, the levels of ALB [ （ 33.47± 4.82 ） g/L vs. （ 30.47 ± 4.64 ） g/L ], PA[ （206.21 ± 41.87 ） mg/L vs. （ 185.62 ± 38.94） mg/L ] and TP [ （ 57.82 ± 5.96） g/L vs. （ 54.47 ± 6. 17 ） g/L] in the treatment group were higher than those in the control group （ t = 2. 456,2. 338,2. 139, all P 〈 0.05 ）. The incidence rates of abdominal distension（ 20.00% vs. 53.33% ） , reflux（ 16.67% vs. 43.33% ） , time of meehanieal ventilation [ （ 11.76 ± 2.02 ） d vs. （ 13.02 ± 1.96） d ] and the stay time in ICU [ （ 13.74 ± 2.31 ） d vs. （ 15.43 ± 2.14） d ] in the treatment group were lower than those in the control group（ χ2 = 7. 177,5.07, t = 2. 452,2. 940, all P 〈 0. 05 ）. There was no statistically significant difference in 28 - day mortality rate （ P 〉 0.05 ）. Conclusion Kangfuxin liquid has helping role on early enteral nutrition in cranioeerebral injury patients with mechanical ventilation. And it is helpful to shorten the time of mechanical ventilation.