丹芪益肾汤治疗糖尿病肾病的效果及对患者尿蛋白的影响

Effect of Danqi Yishen decoction in the treatment of diabetes mellitus and its influence on proteinuria

目的 分析丹芪益肾汤治疗糖尿病肾病的效果及对患者尿蛋白的影响.方法 选取150例糖尿病肾病患者为研究对象,采用随机数字表法分为两组,分别是采取西药治疗的对照组（n=75）、采取丹芪益肾汤治疗的研究组（n=75）,对比两组治疗有效率,治疗前后血肌酐（Cr）、24 h尿蛋白水平和尿素氮（BUN）的改善程度以及治疗前后患者空腹血糖的变化.结果 研究组总有效率高达84.0％,对照组总治疗有效率仅有71.1％,研究组有效率明显高于对照组,两组差异有统计学意义（χ2=7.215,P〈0.05）;治疗前两组各项指标差异均无统计学意义（P〉0.05）,治疗后,研究组各项指标的改善程度均显著高于对照组（均P〈0.05）;治疗后,研究组空腹血糖、餐后2 h血糖以及空腹胰岛素的浓度均明显低于对照组（均P〈0.05）.结论 丹芪益肾汤治疗糖尿病肾病有比较理想的临床效果,显著降低患者尿蛋白以及空腹血糖的含量.

Objective To evaluate the effect of Danqi Yishen decoction on diabetes mellitus （DM） and its influence on proteinuria. Methods 150 DM patients were randomly selected, and they were randomly divided into two groups according to the digital table, 75 cases in each group. The control group was given western medicine, the study group was treated by Danqi Yishen decoction. The treatment efficacy, blood serum creatinine （Cr）, 24h urine protein,blood urea nitrogen （BUN） and fasting blood glucose （FBG） before and after treatment were compared between the two groups. Results The total effective rate of the study group was 84.0%, which was significantly higher than 71.1% of the control group, the difference between the two groups was statistically significant （χ2 = 7. 215 ,P 〈 0.05 ）. Before treatment, there were no statistically significant differences in the health indicators between the two groups （ all P 〉 （1.05）. After treatment, the improvement of indieators of the study group were significantly higher than those of the control group （ all P 〈 0. 05 ）. After treatment, the FBG, postprandial 2h plasma glucose and fasting insulin concentration in the study group were significantly lower than those in the eontrot group （ all P 〈 0. 05 ）. Conclusion Danqi Yishen decoction has ideal clinical effect in the treatment of DM, and can significantly reduce the proteinuria and FBG, which is worthy of widely popularized.