阿托伐他汀联合速效救心丸对老年冠心病患者血脂和血清炎性因子的影响

Influence of atorvastatin combined with Quick Heart - Reliever Pill on blood fat and serum inflammatory factors of elderly patients with coronary artery disease

目的 探讨阿托伐他汀联合速效救心丸对老年冠心病患者血脂和血清炎性因子的影响.方法选取184例老年冠心病患者,采用随机数字表法将其分为对照组和观察组,每组92例.对照组给予阿托伐他汀治疗,观察组给予阿托伐他汀联合速效救心丸治疗.比较两组患者治疗前、治疗1个月后血脂[总胆固醇（TC）,甘油三酯（TG）,高密度脂蛋白胆固醇（HDL-C）,低密度脂蛋白胆固醇（LDL-C）]和血清炎性因子[肿瘤坏死因子α（TNF-α）、C反应蛋白（CRP）、基质金属蛋白酶9（MMP-9）、白细胞介素6（IL-6）].结果治疗1个月后观察组血脂（TC、TG、HDL-C、LDL-C）水平均明显低于对照组[（4.26±0.68）mmoL/L比（5.14±0.61）mmoL/L,（1.51±0.17）mmoL/L比（1.75±0.19）mmoL/L,（1.60±0.38）mmoL/L比（1.52±0.43）mmoL/L,（3.01±0.32）mmoL/L比（3.18±0.42）mmoL/L,t=2.774、2.355、1.976、2.476,均P〈0.05];治疗后1个月观察组血清炎性因子（TNF-α、CRP、MMP-9、IL-6）均明显低于对照组[（50.35±7.47）ng/L比（64.83±8.96）ng/L,（46.50±5.93）mg/L比（57.77±6.48）mg/L,（35.44±6.17）μg/L比（46.85±7.44）μg/L,（16.84±6.72）ng/L比（26.85±9.42）ng/L,t=11.905、12.306、22.159、8.297,均P〈0.05].结论对老年冠心病患者采用阿托伐他汀联合速效救心丸治疗,其临床效果显著,可有效改善患者血脂水平,降低其血清炎性因子水平.

Objective To investigate the effect of atorvastatin combined with Quick Heart - Reliever Pill on blood fat and serum inflammatory factors of elderly patients with coronary artery disease. Methods 184 elderly patients with coronary artery disease were selected, and they were randomly divided into control group and observation grOuP according to the digital table,92 cases in each group. The control group was given atorvastatin treatment,while the observation group was given atorvastatin combined with Quick Heart - Reliever Pill. The levels of serum inflammatory factors （ TNF - or, CRP, MMP - 9 and IL - 6 ） and blood lipid （ TC, TG, HDL - C, LDL - C ） in the two groups after 1 month treatment were compared. Results After 1 month treatment,the blood lipid levels （TC ,TG,HDL - C,LDL - C） of the observation group were significantly lower than those of the control group [ （4.26 ±0.68 ） mmoL/L vs. （5.14 ± 0. 61）mmoL/L,（1.51 ± 0. 17） mmoL/L vs. （1. 75 ±0. 19） mmoL/L, （ 1. 60 ± 0. 38） mmoL/L vs. （ 1.52 ±0. 43） mmoL/L, （3.01 ± 0.32 ） mmoL/L vs. （ 3. 18± 0.42） mmoL/L, t = 2. 774,2. 355,1. 976,2. 476, all P 〈 0. 05 ], and the levels of serum inflammatory factors （ TNF - α, CRP, MMP - 9 and IL - 6） of the observation group were significantly lower than those of the control group [ （50.35 ± 7.47 ） ng/L vs. （ 64.83 ± 8.96 ） ng/L, （46.50± 5.93 ） mg/L vs. （ 57.77 ± 6.48 ） mg/L, （ 35.44 ± 6. 17 ）μg/L vs. （ 46.85 ± 7.44 ） μg/L, （ 16.84 ± 6.72 ） ng/L vs. （26.85 ±9.42）ng/L,t = 11.905,12.306,22. 159,8.297,all P〈0.05]. Conclusion Atorvastatin combined with Quick Heart - Reliever Pill in the treatment of elderly patients with coronary heart disease can achieve notable effects without increasing the liver burden, which can also effectively refine the blood lipid in patients, reduce the inflammatory factors levels, and it is worthy of clinical promotion.