哮喘患儿血清白细胞介素13、鳞状细胞癌抗原的水平变化及意义

Changes of serum levels of interleukin-13 and squamous cell carcinoma antigen in children with asthma and its clinical significance

目的分析哮喘患儿血清白细胞介素13（IL-13）、鳞状细胞癌抗原（SccAg）的水平变化及临床意义。方法选取哮喘患儿45例为观察组，另选择同期体检的健康小儿45例为对照组，采用酶联免疫吸附测定（ELISA）法对两组IL-13、SccAg水平进行检测，探讨哮喘与血清IL-13、SccAg水平的相关性。结果观察组发作期IL-13、SccAg分别为（148．96±24．56）ng／L、（3．36±0．69）μg／L，缓解期分别为（90．65±20．14）ng／L、（2．58±0．34）μg／L，对照组分别为（76．48±17．54）ng／L、（2．30±0．36）μg／L，差异均有统计学意义（F=5．36、6．39，均P〈0．05）。观察组中重度IL-13、SccAg分别为（135．48±21．69）ng／L、（2．86±O．36）μg/L，轻度分别为（160．38±22．45）ng／L、（3．30±0．41）μg/L，对照组分别为（76．48±17．54）ng/L、（2．30±0．36）μg/L，差异均有统计学意义（F=5．78、5．78，均P〈0．05）。哮喘患儿发作期、缓解期血清L-13、SccAg水平均呈明显的正相关性（r=0．982、0．965，均P〈0．05）。结论血清IL-13、SccAg与哮喘的发病有相关性，对判断哮喘发生、发展及转归有一定的临床意义。

Objective To explore the changes of serum interl.eukin-13（IL-13）and squamous cell carcinoma antigen（SccAg）levels in pediatric asthma and its clinical significance.Methods 45 children with pediatric asthma were selected as observation group,45 healthy children at the same time were selected as control group.IL-13 and SccAg levels in the two groups were detected by ELISA.The correlation between the serum IL-13,SccAg levels and pediatric asthma was analyzed.Results In the observation group,the IL-13,SccAg levels at the attack stage were（148.96 ± 24.56）ng/L,（3.36 ± 0.69）μg/L,respectively,the IL-13,SccAg levels at the remission stage were（90.65 ±20.14）ng/L,（2.58 ± 0.34）μg/L,respectively,which in the control group were（76.48 ± 17.54）ng/L,（2.30 ± 0.36）μg/L,respectively,the differences were statistically significant（F = 5.36,6.39,all P 〈 0.05）.In the observation group,the IL-13,SccAg levels in the patients with moderate or severe disease were（135.48 ± 21.69）ng/L,（2.86±0.36）μg/L,respectively,the IL-13,SccAg levels in the patients with mild disease were（160.38 ± 22.45）ng/L,（3.30 ±0.41）μg/L,respectively,which in the control group were（76.48 ± 17.54）ng/L,（2.30 ±0.36）μg/L,respectively,the differences were statistically significant（F = 5.78,6.78,all P 〈 0.05）.The serum IL-13 and SccAg levels had significantly positive correlation with pediatric asthma during the attack stage and remission stage（r = 0.982,0.965,all P 〈 0.05）.Conclusion The serum IL-13 and SccAg levels have certain association with the incidence of asthma,which play an important role in determining the development and reorientation of asthma.