血铅、锌水平与儿童抽动障碍的相关性分析

Correlation analysis of blood lead and zinc with tic disorders in children

目的 分析血铅锌水平与儿童抽动障碍（TD）的相关性。方法 选取114例TD患者作为观察组，同期在该院进行健康体检者100例作为对照组，比较两组儿童的血铅及血锌水平，分析铅及锌与儿童TD的相关性。结果 观察组血铅为（70.8±14.9）μg/L，对照组为（50.9±13.8）μg/L，差异有统计学意义（t＝4.932，P〈0.05）；观察组血锌为（461.4±33.2）μg/L，对照组为（501.5±34.1）μg/L，差异有统计学意义（t＝5.217，P〈0.05）。血铅≥60 μg/L及血锌〈470 μg/L与TD具有显著相关性（OR＝2.192、2.012，均P〈0.05）。结论 血铅锌水平与儿童TD具有显著相关性。

Objective To analyze the correlation between blood lead,zinc levels and tic disorders（TD）in children.Methods One hundred and fourteen children with TD were chosen as observation group,and 100 healthy children were chosen as control group.The serum levels of lead and zinc were compared between the two groups,and the correlation between blood lead,zinc levels and TD was analyzed.Results The serum level of blood lead in the observation group was（70.8±14.9）μg/L,which was higher than（50.9±13.8）μg/L in the control group,the difference was statistically significant（t=4.932,P〈0.05）.The serum level of blood zinc in the observation group was（461.4±33.2）μg/L,which was lower than（501.5±34.1）μg/L in the control group,the difference was statistically significant（t=5.217,P〈0.05）.The serum level of blood lead≥60μg/L and the serum level of blood zinc〈470μg/L were significantly related with TD（OR=2.192,2.012,all P〈0.05）.Conclusion The blood lead and zinc levels are significantly correlated with TD in children.