红霉素联合阿奇霉素治疗小儿支原体肺炎的临床疗效分析

Clinical efficacy of erythromycin combined with azithromycin in the treatment of children with mycoplasma pneumonia

目的 观察红霉素联合阿奇霉素治疗小儿支原体肺炎的临床效果。方法 选取支原体肺炎患儿98例作为研究对象，采用随机数字表法将其分为观察组和对照组各49例。在常规治疗的基础上，对照组采取阿奇霉素治疗，观察组采取红霉素联合阿奇霉素治疗。治疗结束后，观察两组患者的症状消失时间（发热、咳嗽、肺部啰音）、住院时间及不良反应发生情况，进而比较两组患儿的临床疗效。结果 观察组总有效率95.91%，明显高于对照组的79.5%，差异有统计学意义（χ2＝4.721，P〈0.05）。与对照组比较，观察组症状消失时间（发热、咳嗽、肺部啰音）及住院时间均明显缩短，差异均有统计学意义（t＝1.965、1.943、1.987、1.952，均P〈0.01）。对照组不良反应发生率为8.16%，观察组不良反应发生率为12.24%，差异无统计学意义（χ2＝0.445，P〉0.05）。结论 与单用阿奇霉素比较，红霉素联合阿奇霉素治疗小儿支原体肺炎疗效显著，安全性好，有利于缩短疗程，提高有效率。

Objective To explore the clinical efficacy of erythromycin combined with azithromycin in the treatment of mycoplasma pneumonia in children.Methods 98 children with mycoplasma pneumonia were selected.According to the digital chart,the patients were randomly divided into the observation group and control group,with 49 cases in each group.On the basis of routine treatment,the control group was treated with azithromycin,and the observation group received erythromycin combined with azithromycin.After treatment,the disappearance time of the disease（fever,cough,pulmonary rale）,hospitalization time and adverse reactions were observed in the two groups,and the clinical efficacy of the two groups was compared.Results The total effective rate in the observation group was 95.91%,which was significantly higher than that in the control group（79.5%）,and the difference was statistically significant（χ2=4.721,P〈0.05）.Compared with the control group,the disappearance time（fever,cough,pulmonary rales）and hospitalization time of the observation group were significantly decreased（t=1.965,1.943,1.987,1.952,all P〈0.01）.The incidence rate of adverse reactions in the control group was 8.16%,which in the observation group was 12.24%,there was no statistically significant difference between the two groups（χ2=0.445,P〉0.05）.Conclusion Compared with azithromycin alone,erythromycin combined with azithromycin is effective and safe in the treatment of children with mycoplasma pneumonia.It is beneficial to shorten the course of treatment and improve the efficacy,and is worthy of further popularization and application.