苯磺酸左旋氨氯地平与阿托伐他汀钙片合用治疗高血压合并冠心病的临床观察

Clinical observation of （ S） -amlodipine benzenesulfonate combined with atorvastatin calcium tablet in the treatment of hypertension with coronary heart disease

目的 观察苯磺酸左旋氨氯地平与阿托伐他汀钙片两药合用治疗高血压合并冠心病的疗效.方法 选取高血压合并冠心病患者100例,采用随机数字表法分为两组,观察组50例,对照组50例.对照组给予硝苯地平缓释片Ⅱ联合阿托伐他汀钙片治疗;治疗组给予苯磺酸左旋氨氯地平、阿托伐他汀钙片治疗.观察两组总体疗效,治疗前后血脂下降水平,6 min步行试验（6MWT）.结果 血压下降：对照组显效12例,有效23例,无效15例,总有效率70％;观察组显效19例,有效26例,无效5例,总有效率92％,两组差异有统计学意义（χ2=0.95,P〈0.05）;心绞痛发作次数改善：对照组显效10例,有效26例,无效9例,加重5例,总有效率70％;观察组显效18例,有效29例,无效2例,加重1例,总有效率94％,两组差异有统计学意义（χ2=0.12,P〈0.05）;对照组治疗后TC（5.62±1.08）mmol/L,TG（1.95±0.47）mmol/L,LDL-C（3.24±0.71）mmol/L,HDL-C（1.19±0.45）mmol/L,观察组治疗后TC（4.38±0.92）mmol/L,TG（1.90±0.41）mmol/L,LDL-C（1.83±0.62）mmol/L,HDL-C（1.42±0.42）mmol/L,两组治疗后TC、LDL-C差异均有统计学意义（t=2.69、2.41,均P〈0.05）;对照组治疗后6MWT为（362.12±34.60）m,观察组治疗后6MWT为（407.35±29.15）m,两组治疗后差异有统计学意义（t=11.73,P〈0.05）.结论 苯磺酸左旋氨氯地平、阿托伐他汀钙片合用治疗高血压合并冠心病可有效地改善症状,降低血压,提高患者运动耐量,改善患者心功能.

Objective To observe the efficacy of （S）-amlodipine benzenesulfonate combined with atorvastatin calcium in the treatment of hypertension with coronary heart disease .Methods 100 cases were selected and randomly divided into two groups：50 cases in the observation group and 50 cases in the control group .The control group was given nifedipine sustained -release tablets combined with atorvastatin calcium tablets .The treatment group was given （ S） -amlodipine benzenesulfonate combined with atorvastatin calcium tablets .The overall efficacy , the level of dyslipidemia before and after treatment and the 6 -minute walk test （6MWT） of the two groups were observed . Results The decrease of blood pressure：the control group was markedly effective in 12 cases, effective in 23 cases, ineffective in 15 cases,the total effective rate was 70％;The observation group was effective in 19 cases,effective in 26 cases,ineffective in 5 cases,the total effective rate was 92％,the difference between the two groups was statistically significant （χ2 =0.95,P〈0.05）.As to the episodes of angina pectoris ,in the control group,10 cases were markedly effective,26 cases were effective ,9 cases were ineffective ,5 cases were aggravated ,the total effective rate was 70％, which in the observation group were 18 cases,29 cases,2 cases,1 case,the total effective rate was 94％,there was statistically significant difference between the two groups （χ2 =0.12,P〈0.05）.After treatment,the TC,TG,LDL-C, HDL-C levels in the control group were （5.62 ±1.08）mmol/L,（1.95 ±0.47）mmol/L,（3.24 ±0.71）mmol/L, （1.19 ±0.45）mmol/L,which in the treatment group were （4.38 ±0.92）mmol/L,（1.90 ±0.41）mmol/L,（1.83 ± 0.62）mmol/L,（1.42 ±0.42）mmol/L,there were statistically significant differences between the two groups （t=2.69,2.41,all P〈0.05）.（4）6MWT in the control group was （362.12 ±34.60）m after treatment,which of the treatment group was （407.35 ±29.15）m,there was statistically significant difference between the two groups （t =11.73,P 〈0.05）.Conclusion （ S） -amlodipine benzenesulfonate combined with atorvastatin calcium in the treatment of hypertension with coronary heart disease can effectively improve the symptoms , lower blood pressure ,improve patients＇exercise tolerance and heart function .