阻塞性睡眠呼吸暂停综合征患者炎症因子水平及其临床意义

Inflammatory factor levels and clinical significances of patients with obstructive sleep apnea hyperventilation syndrome

目的探讨阻塞性睡眠呼吸暂停综合征(obstructive sleep apnea hyperventilation syndrome,OSAHS)患者的相关炎症因子水平及其临床意义。方法回顾性分析2015年4月-2016年10月本院明确诊断为OSAHS初诊患者107例,应用多导睡眠监测(PSG)107例OSAHS初诊患者和35例正常对照患者的睡眠数据,依据患者疾病严重程度和并发症分组,测定各组白介素6(IL-6)、超敏C-反应蛋白(hs-CRP)、肿瘤坏死因子-α(TNF-α)的水平加以比较分析。结果与对照组相比,OSAHS各组、单纯组、并发症组的氧减指数(ODI4)、睡眠呼吸暂停低通气指数(AHI)、血氧饱和度指数<90%的时间占总监测时间百分比(SIT90)、IL-6、hs-CRP、TNF-α明显升高,差异均有统计学意义(P<0.05);与单纯组相比,并发症组的ODI4、AHI、SIT90、IL-6、hs-CRP、TNF-α明显升高,差异均有统计学意义(P<0.05)。结论OSAHS患者IL-6、hs-CRP、TNF-α炎症因子水平与疾病的分级呈正相关,提示其可能在OSAHS发生发展中起到一定的作用。

Objective To understand the levels and clinical significance of inflammatory factor in patients with obstructive sleep apnea hyperventilation syndrome（OSAHS）.Methods We retrospectively analyzed the sleep data of 107 patients diagnosed as OSAHS from our hospital during April 2015-October 2016.The sleepping data of 107 patients and 35 normal controls were collected with polysomnography（PSG）,and grouped based on the disease severity and complications.The levels of IL-6,hs-CRP,and TNF-α were determined and analyzed.Results Compared to the control group,ODI4,AHI,SIT90,IL-6,hs-CRP,TNF-α of each group of OSAHS,simple group and complication group obviously increased,and the differences were statistically significant（P〈0.05）.The ODI4,AHI,SIT90,IL-6,hs-CRP,TNF-α of complication group were higher than simple group,and the differences were also statistically significant（P〈0.05）.Conclusion The levels of IL-6,hs-CRP and TNF-α in OSAHS patients are positively related to the disease classification,suggesting that IL-6,hs-CRP and TNF-α may play a role in the development of OSAHS.