丹参川芎嗪注射联合神经节苷脂对急性脑梗死患者血液黏稠度、血清SOD水平及NIHSS、Barthel评分的影响

Effects of salvia ligustrazine injection combined with ganglioside on blood viscosity,serum SOD and NIHSS,Barthel function score in patients with acute cerebral infarction

目的探讨丹参川芎嗪注射联合神经节苷脂对急性脑梗死患者血液黏稠度、血清超氧化物歧化酶(SOD)水平及美国国立卫生研究院脑卒中量表(NIHSS)、Barthel评分的影响。方法急性脑梗死患者118例,按照随机数字表法分为观察组和对照组各59例。两组入院时均给予常规对症支持治疗,对照组在常规治疗的基础上给予丹参川芎嗪注射液治疗;观察组在对照组的基础上联合神经节苷脂静脉滴注治疗,疗程均为14 d。治疗后比较两组总有效率,血液流变学指标包括全血比黏度低切、全血比黏度高切、血浆比黏度、血小板聚集率,血清SOD水平,NIHSS及Barthel评分情况。结果观察组治疗总有效率明显高于对照组(χ~2=4.69,P=0.03)。两组全血比黏度低切、全血比黏度高切、血浆比黏度及血小板聚集率均明显下降,且观察组明显低于对照组(P<0.05);观察组血清SOD水平明显高于对照组(t=15.56,P=0.00)。两组治疗后NIHSS评分均显著下降,Barthel评分均显著提高,且观察组改善情况明显优于对照组(均P=0.00)。结论丹参川芎嗪注射联合神经节苷脂治疗急性脑梗死的临床疗效显著,能有效调节患者血液黏稠度,升高血清SOD水平并改善患者NIHSS、Barthel评分。

Objective To investigate the effects of salvia miltiorrhiza injection combined with ganglioside on blood viscosity, serum SOD and NIHSS and Barthel function scores in patients with acute cerebral infarction. Methods 118 acute cerebral infarction patients were randomly divided into observation and control groups （n = 59）. All the patients were given regular symptomatic support treatment, the pa- tients of control group were given Danshen ligustrazine injection; the patients of observation group were given Danshen ligustrazine combined with ganglioside intravenous infusion. After treatment, the total effective rate, hemorheology indexes （including whole blood viscosity, low blood viscosity, plasma specific viscosity, platelet aggregation rate） and the serum SOD level, neurological function （NIHSS） and the daily hying ability （Barthel） scores of the two groups were compared. Results The total effective rate of observation group （89.83%） was signif- icantly higher than that in control group （74.58% ,X2 =4.69, P= 0.03）. After treatment with different regimens, the blood viscosity of the two groups were lower, the whole blood viscosity were higher, the plasma specific viscosity and the platelet aggregation rate were significantly decreased, which were lower in observation group than those in control group. The level of SOD in observation group was significantly higher than that in control group （t= 15.56,P=0.00）. After treatment, the scores of NIHSS in the two groups were significantly lower, and it was lower in observation group than that in control group （t = 10.65, P = 0.00）. After treatment, the Barthel scores of the two groups were high- er, and it was higher in observation group than that in control group （ t = 5.22, P = 0.00）. Conclusions The clinical efficacy of Danshen li- gustrazine injection combined with ganglioside treatment on acute cerebral infarction could effectively regulate the blood viscosity of patients, increase serum SOD level and improve the NIHSS and Barthel function scores.