奥拉西坦注射液对急性一氧化碳中毒迟发性脑病患者疗效观察

Quantitative EEG and event-related potential P300 analysis oxiracetam injection curative effect in the treatment of delayed encephalopathy after acutecarbon monoxide poisoning

目的探索奥拉西坦注射液治疗急性一氧化碳中毒迟发性脑病（DEACMP）的临床疗效。方法选择2014年6月至2016年6月于黑龙江省第二医院治疗并住院的DEACMP患者共52例，按照治疗方法分为治疗组（27例）和对照组（25例），对照组仅采用改善脑部微循环等对症治疗，治疗组在对照组基础上联合应用奥拉西坦注射液治疗。治疗4周，于治疗前后应用定量脑电图（QEEG）和事件相关电位P300评价2组患者的治疗效果。结果与对照组比较，治疗组QEEG所有指标均下降，P300潜伏期均缩短，P300波幅均增宽，差异均有统计学意义（P〈0.05）。结论与传统疗法比较，联合应用奥拉西坦注射液治疗DEACMP患者可改善患者脑部功能康复程度。

Objectiveoevaluateclinical curative effect of oxiracetam injection in the treatment of delayed encephalopathy after acute carbon monoxide poisoning（DEACMP）.MethodsMethods 52 patients with DEACMP were randomly divided into the observation group and the control group,27 cases in the observation group and 25 cases in the control group.The 2 groups were adopted the treatment to improve the cerebral microcirculation and other symptomatic,the observation group on the basis of treatment for the treatment of oxiracetam Injection.Quantitative electroencephalogram（QEEG）and event-related potential P300 were used to evaluate the therapeutic effects of the 2 groups before and after treatment.ResultsAfter treatment,QEEG value and event related potential P300 in observation group were decreased with statistically significant,respectively（P〈0.05）,compared with the control group after treatment,the observation group excepted the occipital lobe,left parietal lobe,left around central and other indicators,QEEG and P300 oflatent period was shortened while the bank widens with statistical significance（P〈0.05）.Conclusion Olathe injection of DEACMP patients recovery have certain curative effect.