循环肿瘤细胞与Ⅰ～ⅡA期宫颈癌临床病理参数的相关性

Correlation of Circulating Tumor Cells with Clinicopathological Parameters in Patients with Stage Ⅰ～ⅡA Cervical Carcinoma

[目的]分析Ⅰ-Ⅱ宫颈癌患者外周血循环肿瘤细胞的表达与其临床病理参数相关性。[方法]以莱尔生物循环肿瘤细胞检测技术检测69例初治Ⅰ-ⅡA期宫颈癌和20例正常人中循环肿瘤细胞的表达情况,并与Ⅰ-ⅡA期宫颈癌临床病理参数做相关分析。[结果]Ⅰ-ⅡA期宫颈癌和正常人中循环肿瘤细胞阳性率分别为47.8%和0（P〈0.05）。在SCC≤1.5ng/ml和SCC〉1.5ng/ml组中,循环肿瘤细胞阳性率分别为33.3%和59.0%（P=0.035）;在无盆腔淋巴结转移和有盆腔淋巴结转移组中,循环肿瘤细胞阳性率分别为39.2%和72.2%（P=0.035）;在无淋巴血管间隙受侵和有淋巴血管间隙受侵组中,循环肿瘤细胞阳性率分别为41.8%和71.4%（P=0.048）。在不同的年龄、病理类型和分期以及是否有宫旁浸润和深肌层浸润的各组中,循环肿瘤细胞表达差异均无统计学意义（P〉0.05）。[结论]循环肿瘤细胞与Ⅰ~ⅡA期宫颈癌盆腔淋巴结转移、淋巴血管间隙受侵和SCC密切相关,可用于评估Ⅰ~ⅡA期宫颈癌的病情。

[Objective]To investigate correlation of circulating tumor cells（CTCs）expression with clinicopathological parameters in stage Ⅰ~ⅡA cervical carcinoma patients,and explore its clinical significance.[Methods]A total of 69 stage Ⅰ ~ Ⅱ A cervical carcinoma patients and 20 healthy people were evaluated by Cyttel Bio CTC detection technology for detecting CTCs,and the correlation of CTCs with patients＇ clinicopathological parameters was also analyzed.[Results]The positive rate of CTCs in patients with stage Ⅰ-Ⅱ A cervical carcinoma and the healthy people was 47.8% and 0,respectively,and the difference was statistically significant（P〈0.05）.In patients with SCC ≤1.5 ng/ml and SCC〉 1.5 ng/ml,the positive rate of CTCs were 33.3% and 59.0%,respectively（P=0.035）.The positive rate of CTCs in patients with negative and positive pelviclymph node metastasis were 39.2% and 72.2%,respectively（P=0.035）,the positive rate of CTCs in patients with negative and positive lymphovascular involvement were 41.8% and 71.4%,respectively（P =0.048）.In patients with different age,histological type,stage,parametrialextension or deepstromalinvation,CTCs expression had no significant difference（P〈0.05）.[Conclusion]CTCs are closely related with stage Ⅰ~ⅡA cervical carcinoma＇s pelviclymph node metastasis,lymphovascular involvement and SCC level,and can be used to evaluate stage Ⅰ~ⅡA cervical carcinoma.