多奈哌齐联合司来吉兰对帕金森病患者氧化应激水平及认知功能的影响

Effect of donepezil combined with selegiline on oxidative stress level and cognitive function in patients with Parkinson's disease

目的观察多奈哌齐联合司来吉兰对帕金森病(PD)患者氧化应激水平及认知功能的影响,探讨多奈哌齐治疗帕金森病的临床效果。方法选取2016年7月—2017年6月接受治疗的PD患者86例作为研究对象,依据随机数表法分为观察组和对照组,各43例。对照组给予司来吉兰治疗,观察组则加用多奈哌齐治疗。观察两组治疗前后氧化应激水平、认知功能与临床疗效、不良反应等。计量资料比较采用t检验,计数资料比较采用χ~2检验,P<0.05为差异有统计学意义。结果两组临床疗效对比,观察组优于对照组,差异有统计学意义(P<0.05);治疗前两组丙二醛(MDA)、超氧化物歧化酶(SOD)、谷胱甘肽(GSH)、简易智能精神状态检查量表(MMSE)评分、蒙特利尔认知评估量表(Mo CA)评分等对比,差异无统计学意义(均P>0.05);治疗后观察组MDA水平低于对照组,MMSE评分、Mo CA评分、SOD、GSH水平高于对照组,差异有统计学意义(均P<0.05);两组不良反应发生率相比,差异无统计学意义(P>0.05)。结论多奈哌齐与司来吉兰联合治疗PD利于调节机体氧化应激水平,提升患者认知功能,缓解PD症状、促进病情转归。

Objective To observe the effect of donepezil combined with selegiline on oxidative stress level and cognitive function in patients with Parkinson＇s disease（PD）,and to explore the clinical effect of donepezil in the treatment of PD.Methods A total of 86 patients with PD treated from July 2016 to June 2017 were selected,and they were divided into observation group and control group by random number table,43 cases in each group.Control group were given selegiline,while observation group was treated with donepezil combined with selegiline.The oxidative stress level,cognitive function,clinical efficacy,adverse reactions in two groups before and after treatment were observed.Measurement data were compared by t test and enumeration data were compared by χ~2 test.P〈0.05 was considered statistically significant.Results The clinical efficacy of observation group was better than that of control group（P〈0.05）.Before treatment,there was no statistical difference in the scores of malondialdehyde（MDA）,superoxide dismutase（SOD）,glutathione（GSH）,mini-mental state examination scores（MMSE）,Montreal cognitive assessment（Mo CA）scores between the two groups（all P〉0.05）.After treatment,the level of MDA in observation group was lower than that in control group,while the MMSE,Mo CA,SOD,GSH in observation group were higher than those in control group（all P〉0.05）.There was no statistical difference in the incidence of adverse reactions between the two groups（P〈0.05）.Conclusion Donepezil combined with selegiline in treatment of PD can regulate oxidative stress level,increase cognitive function,relieve symptoms of PD and promote the prognosis of the disease.