帕利哌酮对儿童精神分裂症患者阴性症状的效果

The effect of Paliperidone on negative symptoms in children with schizophrenia

目的探讨帕利哌酮对儿童精神分裂症患者阴性症状的效果。方法选取2015年6月~2017年5月来本院诊治精神分裂症患儿60例,随机分为帕利哌酮组和阿立哌唑组,各30例,帕利哌酮组给予帕利哌酮治疗,阿立哌唑组给予阿立哌唑治疗,分析所有患者的临床疗效、阴性症状评定量表(SANS)评分、个人社会功能量表(PSP)评分、副反应量表(TESS)评分。结果两组患儿治疗2周后帕利哌酮组患儿SANS五项因子(思维贫乏、情感平淡或迟钝、意志缺乏/情感淡漠、兴趣缺乏/社交缺乏及注意损害)评分开始明显降低,PSP评分开始明显升高,阿立哌唑组治疗后4周SANS评分开始明显降低和PSP评分开始明显升高,帕利哌酮组改善程度好于阿立哌唑组,差异有统计学意义(P<0.05);两组患儿治疗前、治疗后2、4、8周TESS评分均无明显差异(P>0.05)。结论与阿立哌唑相比,帕利哌酮能更好的改善儿童精神分裂症的阴性症状和社会功能,起效快、安全性高。

Objective To discuss the effect of paliperidone on negative symptoms in children with schizophrenia. Methods 60 children with schizophrenia were selected from June 2015 to May 2017 in our hospitals and were randomly divided into the observation group （ n=30 ） and the control group （ n=30 ） . The patients in observation group were given paliperidone, while patients in control group were given aripiprazole. The clinical curative effect, the score of SANS, PSP and TESS of all the patients were analyzed. Results After 2 weeks of the treatment, the SANS score in observation group began to decrease and the PSP scores began to rise, while the patients in control group had same changes after four weeks of the treatment. The degree of improvement in observation group was significantly better than the control group at the same time period （P 〈 0.05 ） . TESS scores of two groups had no significant difference among before treatment and 2, 4, 8 weeks after treatment （P 〉 0.05 ） . Conclusions Paliperidone can improve negative symptoms and social function in children with schizophrenia with quick effect and high safety.