丙戍酸钠缓释片在兴奋冲动的老年痴呆患者中疗效分析

Analysis of curative effect of sodium persulfate sustained-release tablets in patients with Alzheimer's disease

目的研究与分析丙戍酸钠缓释片在兴奋冲动的老年痴呆患者中的治疗效果。方法特选取自2014年5月起~2016年11月于我院接受治疗的老年痴呆患者84例,并按数字表法随机分为对照组40例与观察组44例。对照组采用喹硫平进行治疗,观察组则采用丙戍酸钠缓释片进行治疗。对比两组治疗前后NPI调查分卷评分、MMSE评分、SCAG评分及不良反应发生情况。结果经过治疗后,观察组NPI总分(40.13±11.28)分、激越/攻击因子分(1.08±0.19)分、照料者苦恼程度评分(22.61±7.25)分、MMSE评分(19.96±4.67)分、SCAG评分(39.02±1.37)分等均明显优于对照组NPI总分(49.29±12.35)分、激越/攻击因子分(1.18±0.25)分、照料者苦恼程度评分(26.57±8.83)分、MMSE评分(16.04±3.28)分、SCAG评分(37.79±0.49)分;观察组不良反应发生率(6.82%)明显低于对照组(25.00%),差异有统计学意义(P<0.05)。结论丙戍酸钠缓释片可有效缓解老年痴呆患者精神性兴奋冲动行为,作用效果较优,同时该药无明显副反应,安全性较高。

Objective B To study and analyze the therapeutic effect of sodium tetrandrine sustained-release tablets in patients with Alzheimer＇s disease. Methods Forty - eight patients with senile dementia who were treated in our hospital from May 2014 to November 2016 were randomly divided into control group （n = 40 ） and observation group （ n = 44） . The control group was treated with quetiapine, and the observation group was treated with sodium persulfate sustained-release tablets. The scores of MMSI score, SCAG score and adverse events were compared before and after treatment. Results After treatment, the total score of NPI （ 40.13 ± 11.28 ）, the agitation / attack factor score （ 1.08 ± 0.19 ）, the score of distress score （22.61 ± 7.25 ）, the MMSE score （ 19.96 ±4.67 ）（39.02± 1.37 ） were significantly higher than those in the control group （49.29 ±12.35）, the agitation / attack factor score （ 1.18 ±0.25）, the score of the career （26.57 ± 8.83 ） MMSO score （ 16.04 ± 3.28 ） and SCAG score （ 37.79 ±0.49）. The incidence of adverse re- actions in the observation group （ 6.82 % ） was significantly lower than that in the control group （ 25.00 % ）, the difference was statistically significant （ P 〈 0.05 ） . Conclusion Sodium persulfate sustained-release tablets can effectively relieve the impulsive behavior of senile dementia patients, the effect is better, and the drug has no obvious side effects and high safety.