晚期乳腺癌患者的反刍性沉思水平与焦虑、抑郁的相关性分析

The correlation between rumination and symptoms of anxiety and depression in patients with advanced breast cancer

目的探讨晚期乳腺癌患者的反刍性沉思水平与焦虑、抑郁及生存质量的相关性。方法自2015年1月~2016年12月,前瞻性收集晚期乳腺癌患者120例作为观察组,同期收集健康的成年女性50例作为对照组,观察并对比两组侵入性和目的性反刍性沉思水平、焦虑抑郁水平及生存质量。采用Pearson线性相关的方法来分析患者的反刍性沉思水平与焦虑、抑郁及生存质量的相关性。结果与对照组比较,观察组侵入性反刍性沉思水平、焦虑自我评分、抑郁自我评分显著较高(P<0.05),目的性反刍性沉思和健康相关的生存质量显著较低(P<0.05)。侵入性反刍性沉思与焦虑、抑郁自我评分呈显著正相关(r=0.208、0.268,P<0.05),与健康相关的生存质量呈显著负相关(r=-0.234,P=0.010)。目的性反刍性沉思与焦虑自我评分显著负相关(r=-0.225,P=0.013),与抑郁自我评分和健康相关的生存质量无明显相关(P>0.05)。结论晚期乳腺癌患者侵入性反刍性沉思水平升高、目的性反刍性沉思水平降低,与焦虑抑郁的负性情绪是相关的,并一定程度上影响了患者的生存质量。

Objective To explore the correlation of rumination and anxiety, depression and quality of life in patients with advanced breast cancer. Methods During the period of January 2015 to December 2016, we prospectively collected 120 cases patients with advanced breast cancer as the observation group, and during the same time we collected 50 healthy females as the control group. The invasive and purposeful rumination level, symptoms of anxiety and depression and quality of life were observed and compared between groups. Pearson correlation was used to measure the correlation between rumination and anxiety, depression and quality of life. Results Compared with the control group, the observation group showed elevated level of invasive rumination, self-rating anxiety score and self-rating depression score （P〈0.05）, while exhibited decreased level of purposeful ruminationlevel and health-related quality of life score （P 〈 0.05 ） . Invasive rumination level was positively associated with anxiety and depression scores （ r=0.208 and 0.268, P〈0.05 ）, while negatively associated with the health-related quality of life score （ r=-0.234, P=0.010 ） . Moreover, purposeful rumination level was negatively correlated with the self-rating anxiety score （r=-0.225, P=0.013 ）, and wan non-significantly correlated with self-rating depression score and health-related quality of life （ P 〉 0.05 ） . Conclusion Patients with advanced breast cancer have a higher level of invasive rumination and a lower level of purposeful rumination, which are related to anxiety and depression. And to a certain extent, it might contribute to a lower health-related quality of life.