妊娠糖尿病患者血钾水平与胰岛素抵抗的相关性

Correlation between serum potassium and insulin resistance in patients with gestational diabetes mellitus

目的:探讨妊娠糖尿病(gestational diabetes mellitus,GDM)患者中血钾水平与胰岛素抵抗的相关性分析。方法:根据口服葡萄糖耐量试验(oral glucose tolerance test,OGTT)结果选取200例妊娠糖尿病患者,收集空腹血样本及糖负荷后0.5,1,2 h血样本,测定血脂、血糖、胰岛素及血钾水平等,计算并评价胰岛素抵抗指数(homeostasis model assessment of insulin resistance,HOMA-IR)、胰岛素敏感指数(Matsuda指数)。结果:在妊娠糖尿病患者中,HOMA-IR与孕前BMI,TC,TG呈正相关,与血钾呈负相关;Matsuda指数与孕前BMI,TC,TG呈负相关,与血钾呈正相关。多元逐步回归分析提示,在校正孕前BMI、血脂等因素后,血钾水平仍然与HOMA-IR和Matsuda指数相关,说明血钾水平是胰岛素抵抗指数的独立影响因素。结论:在妊娠糖尿病患者中,血钾水平与胰岛素抵抗密切相关,可为预防和治疗妊娠糖尿病提供新方法。

Objective： To explore the correlation between serum potassium and insulin resistance in patients with gestational diabetes mellitus（GDM）. Methods： A total of 200 GDM patients were enrolled in our study. All patients underwent a standard oral glucose tolerance test（OGTT）. Their clinical, serum potassium and insulin were measured. Insulin secretion indices were measured by homeostasis model assessment of insulin resistance（HOMA-IR） and Matsuda index. Results： In GDM, HOMA-IR was postively correlated with progestation BMI, TC, TG and negatively correlated with serum potassium; Matsuda index was negatively correlated with progestation BMI, TC, TG and postively correlated with serum potassium. The multiple regression model analysis showed that serum potassium was closely correlated to HOMA-IR and Matsuda index independent of any factors. Conclusion： In GDM, serum potassium can influence insulin resistance which provides a new treatment strategy for preventing and therapy GDM.