线粒体在支气管哮喘发病机制及治疗中的研究

Mitochondrion play the role in bronchial asthma pathogenesis and therapeutics

支气管哮喘（简称哮喘）是一个多致病因素的呼吸系统疾病，主要特征包括气道慢性炎症、气道高反应性和气道重塑。线粒体功能失调与哮喘有密切相关性；线粒体作为重要的细胞器，为细胞的活动提供能量，同时参与诸如细胞分化、细胞信息传递和细胞凋亡等过程，调控细胞生长和细胞中的钙离子的动态平衡，并在母系遗传中扮演重要角色。现从线粒体在细胞氧化、硝化应激、凋亡、钙离子动态平衡中的作用，讨论肺的病理学和线粒体生物学间可能的联系，同时展望未来的研究方向，及潜在的治疗策略。

Bronchial asthma（asthma） is a multifaetorial airway disease and is characterized by chronic airway inflammation, airway hyperresponsiveness and airway remodeling. It is considered a powerhouse of the cell, and involved both in the differentiation information transfer and apoptosis process, so it enable to regulate cell growth and cell cycle, indeed, mitochondria can act as buffering organelles in a spatiotemporal manner to maintain the calcium homeostasis. Mitochondria could be important in the inheritance of asthma. We discuss the probable points of intersection between lung pathobiology and mitochondrial biology. Mitochondrial influence on cellular oxidative and nitrative stress, apoptosis, and calcium homeostasis is covered in detail, potential therapeutic new target sites are also discussed.