基于临床病症特点的湿疹动物模型分析

Analysis of eczema animal model based on clinical characteristics

分析现有湿疹动物模型与湿疹临床病症特点的吻合情况及各湿疹动物模型特点，提出相应的湿疹动物模型的评价方法及改进方法。依据中、西医湿疹临床诊断标准，总结当前湿疹模型的特点及造模方法，分析现有动物模型与湿疹临床特点的吻合情况。目前多选用小鼠背部湿疹动物模型，一定程度反映了临床湿疹的病理生理特点。但缺少能反映中医临床特征的病症模型。建立较好反映湿疹中西医临床特点的病症结合模型及湿疹模型指标体系是未来研究的重点。

The coincidence of the existing eczema animal model and the clinical characteristics of eczema, and^the application char- acteristics of eczema animal model were analyzed, and the evaluation method and improvement method of corresponding eczema animal model was put forward. Based on the clinical diagnostic criteria of eczema of traditional Chinese medicine and western medicine, the characteristics of current eczema model and the modeling method were summarized, and the anastomosis situations between the existing animal model and the eczema clinical characteristics were analyzed. At present, the back eczema models of mice have been usually used, which reflected the pathophysiologieal characteristics of clinical eczema to a certain degree. However, the existing animal models fail to reflect the clinical characteristics of traditional Chinese medicine. Future studies focused on establishing animal models that bet- ter reflect the clinical characteristics of eczema and the index system of eczema model.