25-羟维生素D水平与女性特发性良性阵发性位置性眩晕的相关性

Relationship between 25-hydroxyvitamin D levels and idiopathic benign paroxysmal positional vertigo in female patients

目的探讨血清25-羟维生素D[25（OH）D]水平与女性特发性良性阵发性位置性眩晕（BPPV）之间的相关性。 方法选取2016年1至12月在宁波市第二医院神经内科诊治的67例女性特发性BPPV患者作为研究对象，同期选取95例无眩晕/头晕病史的健康女性作为对照组。收集所有研究对象的身高、体重、疾病史等临床资料，并测定血清25（OH）D的浓度。BPPV患者随访1年，记录期间复发以及复位次数。 结果BPPV组与对照组年龄、体质指数及高血压、糖尿病患病比例差异均无统计学意义（均P〉0.05）。BPPV组血清25（OH）D （50.56±13.36）nmol/L，低于对照组的（56.55±16.21）nmol/L，差异有统计学意义（t＝－2.485，P＝0.014）。血清25（OH）D水平低的BPPV患者，其复发频率高，所需复位次数多。多因素logistic回归分析显示25（OH）D缺乏和BPPV发病相关（OR＝2.054，95%CI：1.088～3.877，P＝0.026）。 结论25（OH）D缺乏可能与女性BPPV发病相关。

ObjectiveTo investigate the relationship between serum 25-hydroxyvitamin D[25（OH）D]levels and idiopathic benign paroxysmal positional vertigo（BPPV）in female patients. MethodsA total of 67 women diagnosed with idiopathic BPPV were selected as the study group between January and December 2016 in Ningbo No.2 Hospital,and 95 healthy women without a history of vertigo or dizziness were selected as the control group.The data of height,weight,histories of hypertension and diabetes mellitus were collected,and serum 25（OH）D levels were measured.The number of the recurrence and canalith repositioning maneuvers were recorded during the one-year follow-up. ResultsNo significant differences of age,body mass index,histories of hypertension and diabetes mellitus between patients with BPPV and healthy controls（all P〉0.05）.The serum 25（OH）D levels were significantly lower in patients with idiopathic BPPV than in healthy controls[（50.56±13.36）nmol/L vs（56.55±16.21）nmol/L,t=-2.485,P=0.014].BPPV patients with low level of 25（OH）D showed a significant increase in the number of canalith repositioning maneuvers required and the recurrence rate.The regression analyses demonstrated that 25（OH）D deficiency was associated with BPPV with an odds ratio of 2.054（95% CI：1.088-3.877,P=0.026）. Conclusion25（OH）D deficiency may be a risk factor of BPPV.