催产素对孤独症谱系障碍患者的影响:随机对照试验的系统综述和meta分析

The Impact of Oxytocin in ASD Patients:A Systematic Review and Meta-Analysis

目的:综合评价随机对照试验(RCTs)研究中,催产素(OT)对孤独症谱系障碍(ASD)患者的社交功能和刻板行为的影响。方法:检索Pub Med,Embase,Cochrane library,Psyc INFO和Web of science数据库,并追踪相关参考文献,运用Stata14.0软件进行定量分析。结果:共纳入17篇文献,有关社交功能的16篇文献中,有9篇显示OT有显著促进作用,与刻板行为相关的8篇文献中,只有一项研究发现OT改善了刻板行为。Meta分析结果显示,OT对ASD患者社交功能和刻板行为的合并效应量Hedges’g值分别为0.167(P=0.355)和0.020(P=0.901)。结论:OT对ASD有混合作用,meta分析显示OT对ASD个体的社交功能和刻板行为没有显著影响,鉴于纳入的RCTs研究数量有限,OT对ASD的作用仍需进一步研究。

Objective： To review randomize controlled trials（RCTs） examining the effects of oxytocin（OT） administration on social function and restricted, repetitive behaviors in individuals with ASD. Methods： Literature searches were conducted in PubMed, Embase, Cochrane library, PsycINFO and Web of science, and reference lists from identified articles to re- trieve relevant studies. The results were analyzed using statal4.0 software. Results： 17 RCTs were included in this review. 9 out of the 16 studies that examined social function reported improvements. Additionally, one out of the eight studies on restricted, repetitive behaviors, reported improvements following OT administration. Meta-analysis showed that the combined effect of OT on social function and restricted, repetitive behaviors was 0.167（P=0.355） and 0.020（P=0.901）, respectively. Conclusion： Previous evidence revealed mixed findings about the effects of OT on ASD. Results from our meta-analyses suggest that OT has no significant effect on social function and restricted, repetitive behaviors. Given the limited number of RCTs, our summary of findings on the effectiveness of OT on ASD should still be considered tentative and further studies is still to be need.