摘要
Dear Editor, Clustered regularly interspaced short palindromic repeats （CRISPR） system is part of the adaptive immunity of bacteria and archaea that defends them against phage infection （Barrangou and Doudna, 2016）. Variant CRISPR systems have been identified and harnessed for a wide range of applications in various organisms, exemplified by gene editing with the CRISPR/Cas9 system from Streptococcuspyogenes （Barrangou and Doudna, 2016）.
Dear Editor, Clustered regularly interspaced short palindromic repeats （CRISPR） system is part of the adaptive immunity of bacteria and archaea that defends them against phage infection （Barrangou and Doudna, 2016）. Variant CRISPR systems have been identified and harnessed for a wide range of applications in various organisms, exemplified by gene editing with the CRISPR/Cas9 system from Streptococcuspyogenes （Barrangou and Doudna, 2016）.
基金
We thank Rong and Lin lab members for constructive criticism and discussions. The research was funded by the National Natural Sci- ence Foundation of China （Grant Nos, 81670093 and 81372494）, the Natural Science Foundation of Guangdong Province （2014B020212018 and 2017A030310331）, the Program of Guangzhou Science Technology and Innovation Commission （201508020120）, and the Thousand Young Talents Program of China.
