摘要
Radiation therapy,which uses X-rays to destroy or injure cancer cells,has become one of the most important modalities to treat the primary cancer or advanced cancer.High resolution,water equivalent and passive X-ray dosimeters are highly desirable for developing quality assurance（QA）systems for novel cancer therapy like microbeam radiation therapy（MRT）which is currently under development.Here we present the latest developments of high spatial resolution scintillator based photonic dosimeters,and their applications to clinical external radiation beam therapies：specifically high energy linear accelerator（LINAC）photon beams and low energy synchrotron photon beams.We have developed optical fiber dosimeters with spatial resolutions ranging from 50 to 500 gm and tested them with LINAC beams and synchrotron microbeams.For LINAC beams,the fiberoptic probes were exposed to a 6 MV,10 cm by 10 cm X-ray field and,the beam profiles as well as the depth dose profiles were measured at a source-to-surface distance（SSD）of 100 cm.We have also demonstrated the possibility for temporally separating Cherenkov light from the pulsed LINAC scintillation signals.Using the 50 μm fiber probes,we have successfully resolved the microstructures of the microbeams generated by the imaging and medical beamline（IMBL）at the Australian Synchrotron and measured the peak-to-valley dose ratios（PVDRs）.In this paper,we summarize the results we have achieved so far,and discuss the possible solutions to the issues and challenges we have faced,also highlight the future work to further enhance the performances of the photonic dosimeters.
Radiation therapy,which uses X-rays to destroy or injure cancer cells,has become one of the most important modalities to treat the primary cancer or advanced cancer.High resolution,water equivalent and passive X-ray dosimeters are highly desirable for developing quality assurance（QA）systems for novel cancer therapy like microbeam radiation therapy（MRT）which is currently under development.Here we present the latest developments of high spatial resolution scintillator based photonic dosimeters,and their applications to clinical external radiation beam therapies：specifically high energy linear accelerator（LINAC）photon beams and low energy synchrotron photon beams.We have developed optical fiber dosimeters with spatial resolutions ranging from 50 to 500 gm and tested them with LINAC beams and synchrotron microbeams.For LINAC beams,the fiberoptic probes were exposed to a 6 MV,10 cm by 10 cm X-ray field and,the beam profiles as well as the depth dose profiles were measured at a source-to-surface distance（SSD）of 100 cm.We have also demonstrated the possibility for temporally separating Cherenkov light from the pulsed LINAC scintillation signals.Using the 50 μm fiber probes,we have successfully resolved the microstructures of the microbeams generated by the imaging and medical beamline（IMBL）at the Australian Synchrotron and measured the peak-to-valley dose ratios（PVDRs）.In this paper,we summarize the results we have achieved so far,and discuss the possible solutions to the issues and challenges we have faced,also highlight the future work to further enhance the performances of the photonic dosimeters.
