基于数据挖掘的小儿感冒病倪珠英教授用药规律研究

Study on Medication Rules of Professor Ni Zhuying in Treatment of Pediatric Common Cold Disease based on Data Mining

目的:分析倪珠英教授治疗小儿感冒病的用药规律,总结倪老治疗小儿感冒病临证经验,为临床提供参考。方法:将倪珠英教授门诊病历扫描成电子版存档,并录入结构化临床病例采集系统,选取其中治疗小儿感冒病病例696诊次,用中医传承辅助平台对录入数据进行预处理,再进行用药频次、药物剂量、药类统计等分析,并利用复杂网络系统分析核心药物和常用配伍规律。结果:倪珠英教授治疗小儿感冒病药物使用频次最高前12味药:白芷、金银花、黄芩、陈皮、羌活、桔梗、蜜麻黄、薄荷、炒苦杏仁、麸炒枳壳、瓜蒌皮、前胡,药类前5类依次是清热药、解表药、化痰药、补虚药、理气药。复杂网络分析核心药物组成:蜜麻黄、炒苦杏仁、瓜蒌皮、陈皮、羌活、白芷、黄芩、金银花、薄荷、桔梗、麸炒枳壳、前胡。常用药对配伍:黄芪-麸炒白术-防风,葛根-北柴胡-芦根,鱼腥草-钩藤-法半夏,麸炒神曲-炒山楂,姜黄-生大黄-蝉蜕,苍耳子-辛夷等。结论:倪教授善"从气"、"从痰"、"从热"治疗小儿感冒病,注重"先证治之",主张大剂祛邪。数据挖掘方法可以总结名老中医用药规律,与临床情况较符合,能够更客观的整理总结名老中医的经验,为临床用药提供更多参考。

This paper was aimed to analyze the medication rules of Prof.Ni Zhuying in the treatment of pediatric common cold disease,in order to summary Prof.Ni＇s experiences and to provide references for clinical practice.The information of Prof.Nis outpatient cases was scanned into an electronic version and treated with the structured clinical case collection system.A total of 696 pediatric common cold cases were selected.The data were preprocessed by traditional Chinese medicine（TCM）inheritance platform.And then,the medication frequency,drug dose and drug statistics were analyzed.Core drugs and common compatibility rules were analyzed by complex network system.The top12 drugs with the highest frequency used by Prof.Ni Zhuying in the treatment of pediatric common cold disease were：angelica,honeysuckle,scutellaria root,dried tangerine peel,notopterygium,platycodon root,honey ephedra,mint,fried bitter almond,wheat bran fried fructus aurantii,pericarpium trichosanthis and radix peucedani.The top 5 categories of drugs with the highest frequency were antipyretic medicine,relieving exterior syndrome medicine,reduce phlegm medicine,deficiency tonification medicine,and qi regulation medicine.Complex network analysis of the core drug composition is honey ephedra,fried bitter almond,pericarpium trichosanthis,dried tangerine peel,notopterygium,angelica,scutellaria,honeysuckle,mint,platycodon,wheat bran fried fructus aurantii,and radix peucedani.The compatibility of common drugs were astragalus-wheat bran fried atractylodes-radix saposhnikoviae,pueraria-bupleurum-reed rhizome,houttuynia-uncaria rhynchophylla-rhizoma pinellinae praeparata,wheat bran fried medicated leaven – fried hawthorn,curcumin-rhubarb-periostracum cicada,fructus xanthii-flos magnolia,and etc.It was concluded that Prof.Ni is good at treating pediatric common cold disease from qi,phlegm and heat.Attentions are paid on"Xian-Zheng Zhi-Zhi"and expelling pathogenic factors with large drug dose.Data mining method can summarize the medication rule of famous senior TCM doctors,which is consistent with clinical situation.It can summarize famous TCM doctors＇ experiences,and provide more references for clinical medication.