灰树花蛋白β-葡聚糖的抗抑郁效果及生物学机制研究进展与探析

Research Development of Antidepressant Effect and Biological Mechanism of Grifola Frondosa Proteo-β-glucan

抑郁症已成为现代社会的常见病和多发病,其发病率还在不断升高,重度抑郁症有厌世或自杀的念头。目前西药一直是临床上使用治疗抑郁症的主流药物,但使用这类药物大多表现出起效慢、有效率低、副作用大等缺陷。越来越多的文献显示,我国传统中医药在抑郁症的治疗上具有较好的治疗效果,并且与西医药相比起来更为安全,因而日益受到关注。我国传统医学认为,多食菌类有利于病体康复,药用菌类在中国作为中药用来预防和治疗疾病已具有较长的历史时期。灰树花蛋白β-葡聚糖(Grifola frondosa proteo-β-glucan,GFPβG)是名贵珍稀的药、食同源两用真菌灰树花中的主要活性有效成分。本文对GFPβG的抗抑郁效果及其涉及的生物学机制进行分析综述,为进一步研究抗抑郁新药的开发提供新的理论基础和参考。

Depression has become a common disease in the modern society.The incidence of depression is increasing,and patients with major depressive disorder experience higher rate of suicidal thoughts.Modern medications becomecurrent clinical used antidepressants.Most of these drugs showed disadvantages,including slow-onset,low rate ofefficiency and multiple side-effects.More and more literature shows that Chinese herbal medicine has a potentialtherapeutic effect,and is safer for the treatment of depression.Traditional Chinese medicine（TCM）has been usingpolyphagous fungi for prevention,treatment and recovery of diseases.Grifola frondosa proteo-β-glucan（GFPβG）is themain active ingredients of the rare,valuable,and edible homologous fungus grifola frondosa.This review summarized theantidepressant effect of GFPβG and its biological mechanism,which provided a new theoretical basis for the developmentof novel antidepressant drugs.