香丹注射液联合低分子右旋糖酐对妊娠晚期脐血流阻力增高的影响

Effect of Xiangdan Injection Combined with Low Molecular Dextran on Increase of Umbilical Artery Blood Flow Resistance in Late Pregnancy

目的:观察香丹注射液联合低分子右旋糖酐对妊娠晚期脐血流阻力增高的影响。方法:选取88例妊娠晚期脐血流阻力增高孕妇为研究对象,随机分为治疗组和对照组各44例。治疗组给予香丹注射液联合低分子右旋糖酐治疗,对照组给予硫酸镁注射液治疗。对比2组治疗前后的脐血流收缩期最大血流速度/舒张期末血流速度(S/D)、阻力指数(RI)、搏动指数(PI),记录足月分娩例数,观察不良反应发生情况。结果:治疗前,2组S/D、RI及PI比较,差异均无统计学意义(P>0.05)。治疗后,2组S/D、RI及PI均较治疗前下降,差异均有统计学意义(P<0.05);治疗组S/D、RI及PI均低于对照组,差异均有统计学意义(P<0.05)。治疗组足月分娩率95.45%,对照组足月分娩率79.55%,2组比较,差异有统计学意义(P<0.05)。2组治疗过程中肝肾功能、血常规、小便常规、凝血4项均无明显异常。结论:香丹注射液联合低分子右旋糖酐可降低妊娠晚期脐血流阻力增高患者的脐血流阻力,提高足月分娩率。

Objective：To observe the clinical effect of Xiangdan injection combined with low molecular dextranonincrease of umbilical artery blood flow resistance in late pregnancy.Methods：Selected 88 cases of pregnant women with increased umbilical artery blood flow resistance in late pregnancy and divided them into the treatment group and the control group randomly,44 cases in each group.The treatment group was given Xiangdan injection combined with low molecular dextran for treatment,while the control group was given magnesium sulfate injection for treatment.Compared the maximal systolic flow velocity of umbilical blood flow/end diastolic blood flow velocity（S/D）,resistance index（RI）,and pulsatility index（PI）,recorded the cases of term delivery,and observed occurrence of adverse reactions before and after treatment in both groups.Results：Before treatment,there were no significant difference between the comparisons of S/D,RI,and PI in both groups（P 0.05）.After treatment,S/D,RI,and PI in both groups were all decreased when comparing with those before treatment,differences being significant（P 0.05）.S/D,RI,and PI in the treatment group were all lower than those in the control group,differences being significant（P 0.05）.The rate of term delivery was 95.45% in the treatment group and 79.55% in the control group,difference being significant（P 0.05）.During the treatment of two groups,there were no obvious abnormalities in four indexes including liver and kidney function,blood routine,urine routine,and coagulation.Conclusion：The therapy of Xiangdan injection combined with low molecular dextran can reduce umbilical artery blood flow resistance of patients with increased umbilical artery blood flow resistance in late pregnancy and increase therate of term delivery.