芪玉三龙汤治疗中晚期非小细胞肺癌临床观察

Clinical Observation of Qiyu Sanlong Tang for Non-small Cell Lung Cancer in Moderate and Advanced Stages

目的:观察芪玉三龙汤治疗中晚期非小细胞肺癌(NSCLC)患者的临床疗效与中医证型的关系。方法:选择NSCLC患者31例,在常规治疗的基础上予以芪玉三龙汤口服及对症治疗,观察治疗后患者的临床疗效、生存质量评分、临床症状改善情况、中位生存期、无疾病进展期及1年生存率,以生存质量评价表(FACT-L)对患者生存质量信息进行采集、整理并录入数据库。结果:中晚期非小细胞肺癌患者中医辨证分型中以阴虚热毒型、气虚痰湿型较多,且随着患者患病时间的延长,气阴两虚型所占比重不断增加,芪玉三龙汤对该证型的治疗有效率和生存质量较高,存在优势。卡氏评分越高者临床疗效越好。治疗后,患者临床症状改善明显,生存时间延长,且与芪玉三龙汤干预时间呈正相关。结论:芪玉三龙汤对中晚期NSCLC瘤体稳定有一定作用,对患者的生存质量具有一定的改善作用。

Objective：To observe the relationship between the clinical effect of Qiyu Sanlong tang on patients with non-small cell lung cancer（NSCLC）in moderate and advanced stages and Chinese medicine syndrome types.Methods：Selected 31 cases of patients with NSCLC and gave them oral administration of Qiyu Sanlong tang and symptomatic treatment based on the routine treatment.Observed the clinical effect,scores of quality of life,improvement of clinical symptoms,median survival time,disease-free progressive stage and one-year survival rate of patients after treatment.Applied the assessment scale of quality of life（FACT-L）to collect,organize and record the information on quality of life of patients into the database.Results：In patients with NSCLC in moderate and advanced stages,yin-deficiency and heat-toxin type,qi-deficiency and phlegm-dampness type were of the majority among Chinese medicine syndrome types.With the prolongation of disease course in patients,the proportion of the qi-yin deficiency type was constantly increased,and Qiyu Sanlong tang made higher curative effective rate and quality of life on the qi-yin deficiency type,which had advantages.The higher scores of Karnofsky performed,the better the clinical effect patients had.After treatment,the clinical symptoms of patients were significantly improved,and the survival time was prolonged,which were positively correlated with the intervention time of Qiyu Sanlong tang.Conclusion：Qiyu Sanlong tang has certain effect on the tumor stability of NSCLC in moderate and advanced stages,and has certain improvement on the quality of life of patients.