摘要
生长分化因子-15（growth differentiation factor-15，GDF-15）是一种新的转化生长因子-β（transforming growth factor beta，TGF-β）超家族的成员，关于GDF-15的研究目前主要集中在其抗炎、抗细胞增殖以及抑制肿瘤生长方面。在神经系统中，研究者发现GDF-15是黑质多巴胺能神经元的保护因子、运动和感觉神经元的新的营养因子、脑血管疾病及脑损伤的预测因子。最新研究表明GDF-15还具有调制神经元离子通道的表达、影响突触传递功能的作用。现对GDF-15的生物学特性以及近年来在神经系统疾病中的研究进展进行综述。
Growth differentiation factor-15（GDF-15）is a new divergent member of the transforming growth factor-β（TGF-β）superfamily,Research on GDF-15 is currently focused on its anti-inflammatory,anti-cell proliferation,and inhibition of tumor growth.In the nervous system,researchers found that GDF-15 is a protective factor for nigral dopaminergic neurons,a new trophic factor for motor and sensory neurons,a predictor of cerebrovascular disease and brain damage.Recent studies have shown that GDF-15 also has the function of modulating the expression of neuronal ion channels and affecting the function of synaptic transmission.This review summarizes the biological characteristics of GDF-15 and its recent advances in neurological diseases.
作者
于彦
段淑荣
Yu Yan;Duan Shurong(Neurology Department, the First Affiliated Hospital of Harbin Medical University, Harbin 150001, China)
出处
《神经疾病与精神卫生》
2018年第1期66-69,共4页
Journal of Neuroscience and Mental Health
关键词
生长分化因子-15
脑梗死
认知障碍
帕金森病
综述
Growth differentiation factor-15
Cerebral infarction
Cognition disorders
Parkinson disease
Review
