氧驱雾化吸入普米克令舒对哮喘急性发作患者的影响

Effects of oxygen atomization inhalation of Pulmicort on patients with acute asthma attack

目的分析氧驱雾化吸入普米克令舒对哮喘急性发作患者肺功能及TNF-α、hs-CRP、IL-6、IL-8的影响,探讨该方法对儿童哮喘急性发作期的作用机制。方法选取2014年5月—2017年5月收治的支气管哮喘急性发作患儿100例,随机分为观察组与对照组,各50例。对照组给予止咳、平喘、抗感染、纠正电解质紊乱、祛痰等治疗。观察组在此基础上给予普米克令舒氧驱雾化治疗。比较两组TNF-α、hs-CRP、IL-6、IL-8、FEV1、FVC、PEF等指标。计量资料比较采用t检验,计数资料比较采用χ~2检验,P<0.05为差异有统计学意义。结果观察组总有效率(92.0%)高于对照组(78.0%),差异有统计学意义(P<0.05);治疗后两组TNF-α、hs-CRP、IL-6、IL-8等炎症因子指标均低于治疗前,且观察组均优于对照组,差异均有统计学意义(均P<0.05);治疗后两组FEV1、FVC、PEF等肺功能指标均优于治疗前,且观察组均优于对照组,差异均有统计学意义(均P<0.05)。结论氧驱雾化吸入普米克令舒对儿童哮喘急性发作的作用可能与普米克令舒恢复气道纤毛摆动、舒张支气管平滑肌、抑制体内TNF-α、hs-CRP、IL-6、IL-8等炎症因子的释放,抑制气道高反应有关。

Objective To investigate the effect of oxygen atomization inhalation of pulmicort respules on pulmonary function,TNF-α,hs-CRP,IL-6 and IL-8 levels in patients with acute asthma attack,and to explore the mechanism of this approach on acute attack of childhood asthma.Methods A total of 100 cases of children with acute exacerbation of bronchial asthma from May 2014 to May 2017 were selected and randomly divided into control group and observation group with 50 cases in each group.The control group was only treated with cough,antiasthmatic,anti infection,correction of electrolyte disturbance,expectorant and so on.On the basis,the observation group received Pulmicort oxygenation and atomization therapy.The levels of TNF-α,hs-CRP,IL-6,IL-8,FEV1,FVC and PEF in the two groups were compared.Measurement data were compared by t test,and count data were compared by χ^2 test,P〈0.05 was considered statistically significant.Results The total effective rate（92.0%）in the observation group was higher than that in the control group（78.0%）,the differences were statistically significant（P〈0.05）.After treatment,two groups of inflammatory factors such as TNF-α,hs-CRP,IL-6 and IL-8 were lower than those before treatment,and the observation group was better than the control group,the differences were statistically significant（all P〈0.05）.After treatment,the levels of FEV1,FVC and PEF the two groups were superior to those before treatment,and the observation group were all better than the control group,the difference was statistically significant（all P〈0.05）.Conclusion Oxygen atomization inhalation of pulmicort on acute attack of asthma in children may be associated with the effect of Pulmicort Respules to restore airway cilia beat and relax bronchial smooth muscle,inhibition of the release of TNF-α,hs-CRP,IL-6,IL-8 and other inflammatory factors in the body,inhibition of airway hyperresponsiveness.