急性轻中度脑梗死患者血清Trx、Txnip与认知功能的相关性

The correlation between serum Trx, Txnip and cognitive function in patients with acute mild to moderate cerebral infarction

目的探讨急性轻中度脑梗死患者血清硫氧还蛋白(Trx)、硫氧还蛋白互作蛋白(Txnip)与认知功能的相关性,指导急性轻中度脑梗死后患者认知功能障碍的防治。方法选取2016年5月—2017年4月收治的84例急性轻中度脑梗死患者作为观察组,另选取同时期住院的62例无脑梗死人群作为对照组。采用简易智能精神状态检查(MMSE)对入选患者进行认知功能评估,并检测各组的Trx、Txnip水平。计量资料比较采用t检验,计数资料比较采用χ~2检验,相关性分析采用Spearman等级相关分析。P<0.05为差异有统计学意义。结果观察组的Trx、Txnip水平高于对照组(均P<0.05);观察组MMSE量表总分低于对照组(P<0.05);短时记忆、语言认知域得分低于对照组(均P<0.05);血清Trx、Txnip水平与MMSE量表短时记忆、总分呈负相关关系(r短时记忆=-0.417,-0.433;rMMSE总分=-0.487,-0.428;均P<0.05)。结论急性轻中度脑梗死患者存在认知功能障碍,血清Trx、Txnip水平的增高可能是急性轻中度脑梗死后认知功能障碍的危险因素。

Objective To investigate the correlation between serum Trx,Txnip and cognitive dysfunction in patients with acute mild to moderate cerebral infarction,and to guide the prevention and treatment of cognitive dysfunction in patients with acute mild to moderate cerebral infarction.Methods A total of 84 patients with acute mild to moderate cerebral infarction were collected from May 2016 to April 2017 as the observation group,and 62 patients without cerebral infarction were selected as the control group.The cognitive function of the selected patients was evaluated by MMSE,and the levels of Trx and Txnip were measured.Measurement data were compared by t test and enumeration data were compared by χ^2 test.Spearman level correlation analysis were used to analyze the correlation between indexes and cognitive dysfunction.P〈0.05 was considered statistically significant.Results Compared to the control group,the levels of Trx and Txnip were higher,MMSE scores were less,and scores of short-term memory and language were lower in the observation group（all P〈0.05）.There was a negative correlation between serum Trx,Txnip levels and MMSEscores（rshort-term memory=-0.417,-0.433;rMMSE scores=-0.487,-0.428;all P〈0.05）.Conclusion The increase of Trx and Txnip levels was a risk factor to cognitive dysfunction in patients with acute mild to moderate cerebral infarction.