血清锌与婴幼儿腹泻病的关系研究

Serum zinc concentrations in children with diarrhea

目的通过对比腹泻患儿与同年龄健康体检儿童血清锌及免疫球蛋白水平，探讨血清锌水平与腹泻疾病病程及免疫水平的相关性。方法收集2012年12月至2013年12月期间在中国医科大学附属盛京医院儿科消化病房住院的150例婴幼儿腹泻患者，其中急性组（病程〈2周）90例，迁延性慢性组（病程≥2周）60例。健康对照组为同期在儿童保健科进行健康体检的婴幼儿427例。各组均采用原子吸收分光光度法测定血清锌水平。结果腹泻患儿血清锌水平均明显低于同龄健康儿童，差异均有统计学意义（P均〈0.01）。急性组与迁延性慢性组腹泻患儿各年龄段血清锌水平均无明显差异（P均〉0.05）。腹泻患儿IgG、IgM、IgA水平均明显低于健康对照组（P均〈0.05），迁延性慢性组腹泻患儿的IgA、IgM、IgG水平均明显低于急性组腹泻患儿（P均〈0.05）。Pearson相关性分析结果显示腹泻患儿血清锌水平与免疫球蛋白水平无明显相关性（P〉0.05）。结论腹泻患儿血清锌及免疫球蛋白水平明显低于同龄健康儿童，腹泻患儿血清锌水平与免疫球蛋白水平无相关性。

ObjectiveTo compare serum zinc and immunoglobulin levels between young children with diarrhea and healthy children at the same age,and discuss the correlation between serum zinc level and the disease course and immune level of diarrhea.MethodsThis study was carried out at the Shengjing Hospital of China Medical University between December 2012 and December 2013.A total of 150 young children with diarrhea and 427 healthy children（control group）were included,and the young children with diarrhea were divided into acute diarrhea group（n=90）and chronic diarrhea group（n=60）.Zinc levels for all subjects were measured using a flame atomic absorption spectrophotometer.ResultsMean serum zinc levels in the acute diarrhea group and chronic diarrhea group were significantly lower than those in the control group（P〈0.01）.There was no significant difference in serum zinc levels between the acute diarrhea group and chronic diarrhea group（P〉0.05）.The immunoglobulin IgA,IgM and IgG in the acute diarrhea group and chronic diarrhea group were significantly lower than those in the control group（P〈0.01）,and the immunoglobulin IgA,IgM and IgG in the chronic diarrhea group were significantly lower than those in the acute diarrhea group（P〈0.05）.There were no significant correlations between serum zinc levels and immunoglobulin levels in acute diarrhea group and chronic diarrhea group（P〉0.05）.ConclusionSerum zinc and immunoglobulin levels in young children with diarrhea were significantly lower than those of the same age healthy children,there was no correlation between serum zinc level and immunoglobulin level in young children with diarrhea.