山东汉族孕妇XPC基因rs2228001位点多态性与子痫前期遗传易感性的相关性

ASSOCIATION BETWEEN POLYMORPHISM OF RS2228001 IN XPC GENE AND GENETIC SUSCEPTIBILITY TO PREECLAMPSIA IN HAN PREGNANT WOMEN IN SHANDONG PROVINCE,CHINA

目的探讨XPC基因rs2228001位点多态性与子痫前期易感性相关性。方法以山东地区1 279名正常孕妇为对照组,以978名子痫前期孕妇为病例组,采用实时荧光定量PCR技术对两组孕妇的rs2228001位点进行检测,通过比较两组孕妇rs2228001位点的基因型和等位基因频率有无差异,验证XPC基因rs2228001位点的单核苷酸多态性和子痫前期的易感性有无相关性。结果病例组和对照组XPC基因rs2228001位点基因型及等位基因频率比较差异无显著性(P>0.05)。子痫前期早发组和晚发组、轻度型和重度型rs2228001位点基因型分布和等位基因频率与对照组比较差异均无显著性(P>0.05)。结论 XPC基因rs2228001位点的多态性和子痫前期的易感性无相关性。

Objective To investigate the association between the polymorphism of rs2228001 in the XPC gene and genetic susceptibility to preeclampsia.Methods A total of 1 279 normal pregnant women in Shandong Province,China were enrolled as control group,and 978 pregnant women with preeclampsia were enrolled as case group.Quantitative real-time PCR was used to detect rs2228001,and the genotype and allele frequencies of rs2228001 were compared between the two groups to analyze the association between the single nucleotide polymorphism of rs2228001 in the XPCgene and genetic susceptibility to preeclampsia.Results There were no significant differences in the genotype and allele frequencies of rs2228001 in the XPCgene between the case group and the control group（P〈0.05）.There were no significant differences in the distribution of genotypes and allele frequencies of rs2228001 between the early-/late-onset preeclampsia groups and the control group,as well as between the mild/severe preeclampsia groups and the control group（P〈0.05）.Conclusion There is no association between the polymorphism of rs2228001 in the XPCgene and genetic susceptibility to preeclampsia.