E2F-1与MDM2在食管鳞癌组织表达及意义

EXPRESSION OF E2F-1AND MDM2IN ESOPHAGEAL SQUAMOUS CELL CARCINOMA TISSUE AND ITS SIGNIFICANCE

目的探讨核转录因子-1(E2F-1)、小鼠双微体(MDM2)在食管鳞状细胞癌(食管鳞癌)组织中的表达及其意义。方法随机选取林州市肿瘤医院2008年8月—2009年3月手术切除的食管鳞癌标本49例,并同时取距肿瘤大于5cm处的正常食管组织作为对照。采用免疫组织化学方法检测E2F-1、MDM2在食管鳞癌和正常食管组织中的表达。结果食管鳞癌组织E2F-1、MDM2的表达均明显高于正常食管组织(χ~2=21.598、11.004,P<0.05),E2F-1、MDM2在食管鳞癌组织中的表达与有无淋巴结转移、分化程度、浸润深度及TNM分期有关(χ~2=4.871~11.002,P<0.05)。在食管鳞癌组织中E2F-1与MDM2的表达呈正相关(r=0.455,P<0.05)。结论E2F-1、MDM2的高表达与食管鳞癌的发生、发展有关,且二者的表达具有协同作用。

Objective To investigate the expression of E2 F-1 and MDM2 in esophageal squamous cell carcinoma（ESCC）tissue and its clinical significance.Methods A total of 49 ESCC tissue samples obtained by surgical resection in Linzhou Tumor Hospital from August 2008 to March 2009 were collected.Normal esophageal tissue samples located more than 5 cm away from the tumor were collected as controls.Immunohistochemistry was used to measure the expression of E2 F-1 and MDM2 in ESCC tissue and normal esophageal tissue.Results ESCC tissue samples had significantly higher expression of E2 F-1 and MDM2 than normal esophageal tissue samples（χ^2=21.598 and 11.004,P〈0.05）.The expression of E2 F-1 and MDM2 in ESCC tissue was associated with the presence or absence of lymph node metastasis,degree of tumor differentiation,depth of infiltration,and TNM stage（χ^2=4.871-11.002,P〈0.05）.In ESCC tissue,the expression of E2 F-1 was positively correlated with that of MDM2（r=0.455,P〈0.05）.Conclusion High expression of E2 F-1 and MDM2 is associated with the development and progression of ESCC,and there is a synergistic effect between them.