颈动脉支架成形术对颈动脉狭窄病人认知功能的影响

EFFECT OF CAROTID ARTERY STENTING ON COGNITIVE FUNCTION IN PATIENTS WITH CAROTID ARTERY STENOSIS

目的观察颈动脉支架成形术(CAS)对颈动脉狭窄病人认知功能的影响。方法选取接受CAS治疗的颈动脉狭窄病人60例(支架治疗组)和接受药物治疗的颈动脉狭窄病人60例(药物治疗组)作为研究对象。分别于治疗前、治疗后3d、治疗后6个月时,采用韦氏智力量表对两组病人进行认知功能评估。结果支架治疗组治疗后3d时的知识、算术、数字广度、数字符号、领悟力得分较治疗前有不同程度降低,治疗后6个月时的数字符号、数字广度得分较治疗前及治疗后3d时升高,差异有统计学意义(F=2.66~3.86,P<0.05)。药物治疗组治疗后3d时的木块图得分较治疗前提高,差异有统计学意义(F=3.80,P<0.05)。结论相较于药物治疗,颈动脉狭窄病人行CAS后,虽然早期出现一过性认知功能减退,但远期病人的记忆力以及注意力等有所提高。

Objective To explore the effect of carotid artery stenting（CAS）on cognitive function in patients with carotid artery stenosis.Methods Totally 120 patients with carotid artery stenosis were enrolled in this study,including 60 patients who underwent CAS and 60 who received drug treatment.The cognitive function of patients in two groups was measured with Wechsler Adult Intelligence Scale-Revised in China（WAIS-RC）before treatment and at 3 days and 6 months after treatment.Results In the CAS group,the scores of knowledge,arithmetic,digit span,digit symbol,and comprehension at 3 days after treatment were significantly lower than those before treatment;the scores of digit symbol and digit span at 6 months after treatment were significantly higher than those before treatment or at 3 days after treatment（F=2.66-3.86,P〈0.05）.The score of block pattern in the drug treatment group at 3 days after treatment was significantly higher than that before treatment（F=3.80,P〈0.05）.Conclusion Compared with drug treatment,the carotid artery stenosis patients treated by CAS experience temporary cognitive decline in the early stage,but the long-term memory and attention will be improved.