角膜接触镜作为眼部药物递送系统的研究进展

Advances in Contact Lenses as Ocular Drug Delivery System

角膜接触镜具有良好的生物相容性和较长的佩戴时间,可以作为理想的眼部药物递送系统。载药的角膜接触镜可以延长药物在眼部的停留时间,提高生物利用度。笔者综述了角膜接触镜作为眼部药物递送系统的优势、促进药物局部吸收的机制、载药方法和释放特点以及载药对物理性质的影响。

Contact lenses have good biocompatibility and long wearing duration,and can be used as promising ocular drug delivery system.Drug loading contact lenses can retain the drug on the surface of eye and thus improve the bioavailability.In this review,we summarized the advantage of contact lenses as ocular drug delivery system,mechanism of improving drug absorption,drug loading method and release behavior,and influence of drug loading on physical properties of contact lenses.