不同剂量腺苷蛋氨酸治疗肝癌合并抑郁的观察

Observation of different doses of adenosine methionine in the treatment of liver cancer complicated with depression

目的观察不同剂量腺苷蛋氨酸治疗肝癌合并抑郁的效果。方法 68例肝癌合并抑郁患者,根据使用腺苷蛋氨酸剂量不同分为低剂量组(32例)及高剂量组(36例)。低剂量组患者给予腺苷蛋氨酸500 mg,1次/d,高剂量组患者给予腺苷蛋氨酸1000 mg,2次/d。比较两组治疗效果。结果治疗前,两组患者丙氨酸氨基转移酶(ALT)、天冬氨酸转氨酶(AST)、总胆红素(TBIL)、直接胆红素(DBIL)及凝血酶原时间比较,差异无统计学意义(P>0.05)。低剂量组在治疗2、4周后肝功能指标、焦虑及抑郁评分与治疗前比较均有改善,但差异无统计学意义(P>0.05),高剂量组在治疗4周后肝功能指标与治疗前比较,差异有统计学意义(P<0.05)。高剂量组治疗前抑郁评分为(21.2±5.9)分,治疗4周后为(8.1±2.3)分,比较差异具有统计学意义(P<0.05),治疗前后焦虑评分比较差异无统计学意义(P>0.05)。低剂量组治疗前及治疗4周后抑郁、焦虑评分比较,差异无统计学意义(P>0.05)。两组患者均无明显不良反应。结论高剂量腺苷蛋氨酸治疗肝癌并抑郁患者效果更显著。

Objective To observe the effect of different doses of adenosine methionine in the treatment of liver cancer complicated with depression.Methods A total of 68 patients with liver cancer complicated with depression were divided by different doses of adenosine methionine into low-dose group（32 cases）and highdose group（36 cases）.Low-dose group received 500 mg of adenosine methionine by 1 time/d,and high-dose group received 1000 mg of adenosine methionine by 2 times/d.The treatment effect in two groups was compared.Results Before treatment,both groups had no statistically significant difference in alanine aminotransferase（ALT）,aspartate aminotransferase（AST）,total bilirubin（TBIL）,direct bilirubin（DBIL）and prothrombin time（P〉0.05）.Low-dose group had improved liver function index,anxiety and depression score after 2 and 4 weeks of treatment,comparing with before treatment,but the difference was not statistically significant（P〉0.05）.Highdose group had statistically significant difference in liver function index after 4 weeks of treatment,comparing with before treatment,and the difference was statistically significant（P〈0.05）.High-dose group had depression score before treatment as（21.2±5.9）points and（8.1±2.3）points after 4 weeks of treatment,and the difference was statistically significant（P〈0.05）.Before treatment,there was no statistically significant difference in anxiety score before and after treatment（P〉0.05）.Low-dose group had no statistically significant difference in depression and anxiety score before treatment and after 4 weeks of treatment（P〉0.05）.Both groups had no obvious adverse reactions.Conclusion High-dose adenosine methionine is more effective in the treatment of HCC and depressive patients.