表皮生长因子受体在肿瘤发生、发展中的研究进展

Progress in research on role of epidermal growth factor receptor in tumorigenesis and tumor development

表皮生长因子受体(epidermal growth factor receptor,EGFR)是一种具有酪氨酸激酶活性的膜表面蛋白,普遍表达于人体的表皮细胞和基质细胞,并在人类多种肿瘤细胞中高表达。EGFR在一系列恶性肿瘤的发生发展中起重要作用,对促进肿瘤细胞生长、细胞增殖、血管生成、肿瘤细胞侵袭、转移及细胞凋亡均有一定的调节作用。EGFR的表达水平可作为判断多种肿瘤预后的指标。本文主要对EGFR在肿瘤发生和发展中的研究进展作一综述。

Epidermal growth factor receptor（EGFR）,a membrane protein with tyrosine kinase activity,is expressed in human epidermal cells and stromal cells,and is highly expressed in a variety of human tumors.It is also involved in the development of a series of malignant tumors,which plays an important role in promoting the growth,proliferation,angiogenesis,invasion,metastasis and apoptosis of tumor cells,and shows a certain regulatory effect.The expression level of EGFR may be used as a prognostic indicator of various tumors.This paper reviews the progress in research on the role of EGFR in tumorigenesis and tumor development.