坦度螺酮与艾司西酞普兰治疗广泛焦虑症患者的临床效果比较

Effect comparison of Tandospirone and Escitalopram in generalized anxiety disorders

目的探究广泛焦虑症患者在使用坦度螺酮与艾司西酞普兰治疗后的效果比较。方法研究对象为肇庆市第三人民医院2015年10月至2017年10月收治的80例广泛焦虑症患者,将其采用随机数字表法分为治疗1组与治疗2组,40例治疗1组患者采用坦度螺酮治疗,另40例治疗2组患者采用艾司西酞普兰治疗。探讨实施不同治疗对各组患者的焦虑自评量表(SAS)、治疗效果、不良反应发生率、生活质量及智残程度的影响。结果在SAS评分上,治疗后3周治疗1组患者的SAS评分显著比治疗2组高(P<0.05),但治疗前及治疗后6、9、12周治疗1组患者的SAS评分与治疗2组相比,差异均无统计学意义(均P>0.05);治疗总有效率两组相比,治疗1组(72.5%)与治疗2组(70.0%)相比差异无统计学意义(P>0.05);在不良反应发生率上,治疗1组(7.5%)显著比治疗2组(25.0%)低(P<0.05),而在生活质量日常生活能力量表(ADL)、成人智残量表评分上,两组治疗前和治疗后的组间比较差异均无统计学意义(均P>0.05),但两组患者治疗后ADL、成人智残量表评分相比本组治疗前,差异有统计学意义(P<0.05)。结论广泛焦虑症患者使用坦度螺酮与艾司西酞普兰治疗时,两种药物均能有效改善患者病情,但是采用艾司西酞普兰治疗起效快,不良反应发生率高,但患者可耐受,程度较轻,临床治疗中应根据患者具体情况酌情选择药物。

Objective To compare the therapeutic effect of Tandospirone and Escitalopram in generalized anxiety disorders （GAD）Methods 80 GAD patients treated from October 2015 to October 2017 in the Third People＇s Hospital of Zhaoqing city were selected and randomly assigned to Group one （Tandospirone） and Group two （Escitalopram）, 40 cases each group.The SAS （self-rating anxiety scale） points, therapeutic effect, adverse event rate life quality and intelligence disability were probed.Results After 3w of treatment, the SAS points in the Group one were significantly higher than Group two （P〈0.05）; before treatment and after 6w, 9w and 12w of treatment, the SAS points for two groups were not significantly different （P〉0.05）; the total efficiency in the Group one （72.5%） and Group two （70.0%） were not significantly different （P〉0.05）; the adverse event rate in the Group one （7.5%） was significantly lower than Group two （25.0%） （P〈0.05）; before and after treatment,the ADL （activity of daily living） points and Adult Intelligence Scale points for two groups were not significantly different （P〈0.05）.Conclusions Both of Tandospirone and Escitalopram have the fair effect in the improvement of GAD. However, Escitalopram is featured as fast onset, lower adverse event rate and tolerance. In clinical practice, the proper drugs can be selected according to the patient＇s conditions.