丁苯酞联合阿托伐他汀对急性脑梗死患者血流动力学及血清SOD、GSH-Px、NO水平的影响

Effects of butylphthalide combined with atorvastatin treatment on hemodynamics and serum levels of SOD, GSH-Px and NO of patients with acute cerebral infarction

目的:观察丁苯酞联合阿托伐他汀治疗急性脑梗死患者的疗效及对患者血流动力学及血清超氧化物岐化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)、一氧化氮(NO)水平的影响。方法:选取2014年4月至2016年8月鹤壁煤业集团有限责任公司总医院神经内科收治的急性脑梗死患者,按数字随机表法分为试验组和对照组,对照组患者在常规治疗的基础上给予阿托伐他汀钙片治疗,试验组患者给予丁苯酞软胶囊和阿托伐他汀钙片治疗。比较两组治疗效果,并分别于用药治疗前和治疗14 d后采集肘静脉血,检测血流动力学指标和血清SOD、GSH-Px、NO水平及不良反应发生情况。结果:试验组治疗有效率为92.86%(52/56),对照组为78.57%(44/56),组间差异具有统计学意义(P<0.05);与治疗前比较,治疗后14 d两组患者血浆黏度、全血高切黏度、全血低切黏度、红细胞压积、红细胞变形指数等血流动力学指标均明显改善,且试验组患者在上述指标的改善程度较对照组患者更为明显(P<0.05);与治疗前比较,治疗后14 d两组患者血清SOD、GSH-Px水平均明显升高,NO水平明显降低,且试验组患者在上述指标的升高或降低程度较对照组患者更为明显(P<0.05);两组患者用药治疗后均未出现药物相关不良反应。结论:丁苯酞联合阿托伐他汀治疗急性脑梗死患者的临床疗效显著,可有效改善患者血流动力学和氧化应激水平,且安全性高,值得临床推广应用。

Objective： To observe the efficacy of butylphthalide combined with atorvastatin treatment for patients with acute cerebral infarction and the effects on hemodynamics and serum levels of superoxide dismutase（SOD）, glutathione peroxidase（GSH-Px） and nitric oxide（NO）. Methods： Totally 112 patients with acute cerebral infarction admitted on the department of neurology of our hospital from April 2014 to August 2016 were selected and divided into experimental group and control group, each with 56 cases. The patients in the control group received atorvastatin calcium tablets on the basis of conventional therapy, and those in the experimental group received butylphthalide soft capsules combined with atorvastatin calcium tablets. The efficacy was compared between the two groups, and the hemodynamics and serum levels of SOD, GSH-Px, and NO before and after treatment were determined and compared. The incidence of side effects was recorded after administration of medications in the two groups. Results： The effective rate of the treatment group was 92.86%（52/56）, and that of the control group was 78.57%（44/56）, with statistically significant difference（P〈0.05）. Compared with the baseline levels, the hemodynamic indexes such as plasma viscosity, whole blood high shear viscosity, whole blood low shear viscosity, hematocrit and erythrocyte deformation index of both groups were significantly improved, in larger magnitude in the experimental group（P〈0.05）; Compared with those before treatment, the serum levels of SOD and GSH-Px of both groups were significantly increased, the serum levels of NO of both groups were significantly decreased, and experimental group increased or decreased more than control group, with statistically significant difference（P〈0.05）. There was no drug-related adverse reaction after drug treatment in both groups. Conclusion： Butylphthalide combined with atorvastatin treatment has significant clinical efficacy for patients with acute cerebral infarction, and can effectively improve the patients＇ hemodynamics and oxidative stress with high safety, which is worthy of clinical promoation and application.