Box-Behnken响应面法优选七味双花柴胡胶囊的水提工艺

Optimization of Water Extraction Process of Qiwei S Shuanghua Chaihu Capsule by Response Surface Methdology

目的:采用Box-Behnken响应曲面法优化七味双花柴胡胶囊的水提工艺。方法:以绿原酸提取率为指标,在对提取次数、加水量、提取温度和提取时间进行单因素考察的基础上,用Box-Behnken响应曲面法筛选提取工艺的最佳条件。结果:优选出的最佳提取工艺为提取温度87℃,加入12倍量水,提取时间为0.5 h,提取2次。结论:采用Box-Behnken响应曲面法优选的提取工艺稳定,合理可行,为七味双花柴胡胶囊水提工艺的优化提供了实验依据。

Objective： Box-Behnken Response Surface Methodology was used to optimize the water extraction process of Qiwei Shuanghua Chaihu capsule. Methods： Based on chlorogenic acid extraction rate, the extraction times, the amount of water, the extraction temperature and the extraction time were investigated on the basis of single factor, Box-Behnken response surface method was used to screen the optimal conditions of the extraction process. Results ： The optimal extraction process was as follows： the extraction temperature was 87 ℃, the amount of water was 12 times, extraction time was 0. 5 h, and extrac- tion times was 2. Conclusion： The method of Box-Behnken response surface extraction is stable and feasible, which provides the experimental basis for the optimization of water extraction technology of Qiwei Shuanghua Chaihu capsule.