红霉素联合阿奇霉素治疗小儿肺炎支原体肺炎的临床效果及药学分析

Clinical effectiveness and pharmaceutical analysis of treatment combining erythromycin and azithromycin in children with mycoplasma pneumoniae pneumonia

目的评价对肺炎支原体肺炎患儿进行治疗的过程中予以红霉素联合阿奇霉素治疗的效果,评定临床应用价值。方法选入我院于2015年4月~2016年4月期间所收治的肺炎支原体肺炎患儿共60例,予以随机数字表法将其平均分为观察组和对照组,每组各30例。两组患儿均予以红霉素药物治疗,在此基础上,观察组患儿加用阿奇霉素,对比两组患儿治疗后指标。结果观察组患儿无效率10.0%低于对照组的33.3%,差异有统计学意义(P<0.05);同时观察组患儿的退热时间、咳嗽好转时间、啰音消失时间以及住院时间分别为(2.70±1.62)d、(3.22±0.50)d、(5.50±2.30)d、(7.20±1.62)d,对照组的上述指标分别为(3.56±1.70)d、(3.95±0.90)d、(7.51±2.50)d及(8.50±2.10)d,差异有统计学意义(P<0.05)。结论将红霉素联合阿奇霉素应用于肺炎支原体肺炎病症的治疗中,患儿的病症改善时间有所缩短。

Objective To investigate the effectiveness of treatment combining erythromycin and azithromycin in children with mycoplasma pheumoniae pneumonia and evaluate its value of clinical application. Methods 60 children with mycoplasma pneumoniae pneumonia in our hospital from April, 2015 to April, 2016 were divided into observation group and control group with 30 children in each by using random number table. Children in two groups were treated with medication of erythromycin and children in observation group were treated with additional azithromycin. Indicators of children in two groups after treatment were compared. Results The rate of ineffectiveness in observation group（10.0%）was lower than that in control group（33.3%）（P〈0.05）. The fever clearance time, the improvement time of cough, the disappearance time of pulmonary rales and time of hospitalization in observation group were significantly different with those in control group（2.70±1.62）d vs（3.56±1.70）d,（3.22±0.50）d vs（3.95±0.90）d,（5.50±2.30）d vs（7.51±2.50）d,（7.20±1.62）d vs（8.50±2.10）d）（P〈0.05）. Conclusion Time to disease improvement in children with mycoplasma pneumoniae pneumonia decreased when given treatment combining erythromycin and azithromycin.