增殖性玻璃体视网膜病变发病机制及研究进展

Pathogenesis and research progress of proliferative vitreoretinopathy

增殖性玻璃体视网膜病变主要是孔源性视网膜脱离后长时间未得到复位,在玻璃体腔及视网膜内外表面未有纤维细胞性膜(无血管)形成和收缩的病变类型;增殖性玻璃体视网膜病变是导致孔源性视网膜脱离复位手术的失败主要原因,与此同时,增殖性玻璃体视网膜病变也是导致视网膜脱离的重要因素,其成因与玻璃体病理性纤维化相关。当前主要采取的治疗手段为手术治疗,但效果并不十分理想。为了进一步提高治疗效果,本文主要就增殖性玻璃体视网膜病变发病机制及研究现状进行相关探讨,以期为增殖性玻璃体视网膜病变的临床治疗提供更为可靠的理论依据。

Proliferative vitreoretinopathy is a lesion having no fibrocellular membrance（avascular） formation and contraction in the vitreous cavity and the inner and outer retinal surfaces, with retina not been reset for a long time after hegmatogenous retinal detachment. Proliferative vitreoretinopathy will increase the rhegmatogenous retinal detachment,which is the main reason of surgery failure. At the same time, proliferative vitreoretinopathy is also an important factor leading to retinal detachment, and its causes are associated with vitreous pathological fibrosis. Currently the main treatment is surgical treatment, but the effect is not very satisfactory. In order to further improve the therapeutic effect, this article focuses on the pathogenesis and research status of proliferative vitreoretinopathy, in order to provide a more reliable theoretical basis for the clinical treatment of proliferative vitreoretinopathy.