不同剂量辛伐他汀治疗脑梗死的临床效果

Clinical effects of different doses of simvastatin in the treatment of cerebral infarction

目的探讨不同剂量辛伐他汀治疗脑梗死的临床效果。方法抽取至我院就诊的脑梗死患者106例(2016.7.12~2017.7.12)作为本次的研究对象,依照随机数字表法进行分组,每组均53例,对两组患者分别采取不同剂量的辛伐他汀治疗,对比两组的治疗效果。结果治疗前两组的NFDS评分无明显差异(P>0.05),治疗后实验组的NFDS评分相比常规组明显较低(P<0.05);实验组与常规组的治疗总有效率分别为92.45%与77.36%,组间比较数据差异显著(P<0.05);实验组与常规组的不良反应发生率分别为7.55%与5.66%,组间比较数据无明显差异(P>0.05)。结论对脑梗死患者采取较大剂量的辛伐他汀治疗可降低神经功能的受损程度,使得治疗效果提高,药物安全有效,值得采纳。

Objective To investigate the clinical effects of different doses of simvastatin in the treatment of cerebral infarction. Methods 106 patients with cerebral infarction who were admitted to our hospital were selected from2016.7.12 to 2017.7.12 as the study subjects. According to the random number table method, the patients were divided into groups, with 53 patients in each group. Two groups of patients were given different doses of simvastatin for treatment. The treatment effect was compared between the two groups. Results There was no significant difference in NFDS score between the two groups before treatment（P〉0.05）. After treatment, NFDS score in the experimental group was significantly lower than that in the conventional group（P〈0.05）; the total effective rates in the experimental group and the conventional group were 92.45% and 77.36% respectively after treatment, with significant difference between the two groups（P〈0.05）; the incidence rates of adverse reactions in the experimental group and the conventional group were7.55% and 5.66% respectively, and there was no significant difference between the two groups（P〉0.05）. Conclusion The higher dose of simvastatin in the patients with cerebral infarction can reduce the damage of neurological function and improve the treatment effect, which is safe and effective, and is worthy of being adopted.