脑钠肽在老年心力衰竭诊断及预后评估价值

Value of Brain Natriuretic Peptide in the Diagnosis and Prognosis of Elderly Patients with Heart Failure

目的研究分析脑钠肽在老年心力衰竭诊断及预后评估价值。方法根据随机数字表法抽取在本研究接受心力衰竭治疗的100例老年患者作为研究对象,且将其纳进研究组。按照NYHA标准对100例研究对象进行分级,其中心功能为Ⅰ、Ⅱ、Ⅲ、Ⅳ级以此将其设置为甲组、乙组、丙组、丁组,每组25例。此外,再选择于本院接受健康体检的25名人员纳进对照组。结果对比观察组与对照组,超敏肌钙蛋白、脑钠肽、肌红蛋白三个实验室指标经对比,差异有统计学意义(P<0.05),此外,在脑钠肽中,除甲组与对照组对比,其差异无统计学意义,其他乙组、丙组、丁组任意两组经对比,差异均有统计学意义(P<0.05);在超敏肌钙蛋白、肌红蛋白中,丙组、乙组心与对照组、甲组、乙组对比,差异均有统计学意义(P<0.05);观察组心力衰竭老年患者脑钠肽与左室舒张末内径、左室射血分数进行相关性分析,左室舒张末内径与脑钠肽呈正相关(P<0.05),左室射血分数与脑钠肽呈负相关(P<0.05)。结论脑钠肽在老年心力衰竭的临床诊断中具有极高的应用价值,可准确评估患者的预后,此法值得在各大基层医院中推广使用。

Objective To study the value of brain natriuretic peptide in diagnosis and prognosis of elderly heart failure. Methods According to the random number table method, 100 elderly patients treated with heart failure in this study were selected as subjects and included in the study group. In accordance with the NYHA standard, 100 subjects were graded and their central functions were grades Ⅰ、Ⅱ、Ⅲ and Ⅳ to set them as group A, group B, group C, and group D, with 25 cases in each group. 25 persons who were selected for physical examination in our hospital were included in the control group. Results The comparison between the observation group and the control group resulted in the comparison of three laboratory indicators of troponin, brain natriuretic peptide, and myoglobin, with statistically significant differences （P〈0.05）. In addition, brain natriuretic peptides were excluded from the group A. The difference between the control group and the control group was not statistically significant. The other two groups were compared between the two groups, the C group and the D group. The difference was statistically significant （P〈0.05）. In the hypersensitivity troponin and myoglobin, the C group, Differences between group B and control group, group A and group B, statistical significance （P〈 0.05）; correlation analysis between brain natriuretic peptide and left ventricular end-diastolic diameter and left ventricular ejection fraction in elderly pa- tients with heart failure in observation group. The systolic diastolic diameter was positively correlated with brain natriuretic peptide （P〈0.05）, and the left ventricular ejection fraction was negatively correlated with brain natriuretic peptide. Conclusion Brain natriuretic peptide has a high application value in the clinical diagnosis of heart failure in the elderly. It can accurately evaluate the prognosis of patients. This method is worthy of promo- tion in major grass-roots hospitals.