自制维生素D纱条联合克霉唑阴道片治疗念珠菌性阴道炎的临床疗效

Clinical efficacy of self-made vitamin D yarn and Clotrimazole Vaginal Tablets in the treatment of Candida vaginitis

目的白色念珠菌性阴道炎临床上常见的易反复发作的妇科疾病,多见于绝经后妇女,本文旨在探讨自制维生素D纱条联合克霉唑阴道片治疗念珠菌性阴道炎的临床疗效。方法以本院2013~2016年收治的68例白色念珠菌阴道炎绝经妇女作为研究对象,随机分成两组,对照组和实验组各34例。其中实验组运用自制的维生素D纱条联合克霉唑阴道片阴道给药,对照组单独使用克霉唑阴道片进行治疗,随访后对两组数据统计分析。结果 3个月的随访中,实验组治愈17例,显效7例,有效8例,无效的2例,总有效率为94.12%,而对照组的结局显示治愈10例,显效6例,有效7例,无效11例,合计总有效率67.65%。经比较,实验组的疗效显著高于对照组,差异有统计学意义(Χ2=8.84,P<0.005);6个月的随访中,患者血清中25-羟基维生素D水平明显升高差异有统计学意义(P<0.05)。结论自制维生素D纱条联合克霉唑阴道片治疗念珠菌性阴道炎效果较好,血清中的25-羟基维生素D水平提升明显,可尝试在临床上推广使用。但纳入病例较少,需要多中心、大样本的研究进一步证实。

Objective Candida albicans vaginitis is a high incidence and easily recurrent gynecological disease, which is more common in post- menopausal women. This article aims to explore the clinical efficacy of using self-made vitamin D yarn combined with Clotrimazole Vaginal Tablets in the treatment of Candida vaginitis. Methods 68 cases of postmenopausal women with Candida albicans vaginitis in our hospital were selected 2013-2016, and it was randomly divided into two groups, the control group and the experimental group were 34 cases, respectively. Self-made vitamin D gauze combined with Clotrimazole Vaginal Tablets was used by vaginal delivery for treatment in the experimental group. And the control group was treated with Clotrimazole Vaginal Tablets alone, and the statistical analysis of the two groups after follow-up. Results In the experimental group, 17 cases were cured, and 7 cases were apparently effective, 8 cases effective, 2 cases ineffective and the total effective rate was 94.12%, In the control group, 10 cases were cured, and 6 cases were apparently effective, 7 cases effective, 11 cases ineffective and the total effective rate was 67.65%. 6 months＇ follow-up showed that serum levels of 25-hydroxy vitamin D were significantly increased, which was significantly lower than that in the experimental group, and the difference was statistically significant （P〈0.05）. Conclusion There is a curative effect by using self-made vitamin D gauze combined with Clotrimazole Vaginal Tablets in the treatment of candidal vaginit. And the levels of serum 25-hydroxy vitamin D in- creased significantly in the experimental group, but more cases and longer follow-up are needed for further research.