Pyk2参与细胞信号转导通路的研究进展

The research advance of Pyk2 involved in signal transduction pathways

富含脯氨酸的酪氨酸激酶2(proline-rich tyrosine kinase 2,Pyk2)广泛存在于细胞和组织中,参与多种生理及病理过程,发挥其生物学效应。Pyk2依赖N-末端、C-末端和中心激酶结构3个部分实现其对细胞外信号的迅速反应,通过膜联受体活化及自磷酸化等机制实现其自身的活化,激活下游信号分子,进而启动细胞信号转导通路,最终发生一系列细胞形态及功能变化。就目前对Pyk2参与细胞信号转导通路的研究进行综述,以期深入而全面地了解Pyk2的作用,为相关疾病的诊疗提供新的思路。

Proline-rich tyrosine kinase 2（Pyk2） widely exists in cells and tissues,involved in multiple physiological and pathological processes and exerts biological influence. Pyk2 can rapidly response to the extracellular signals depending on the structures of a central kinase domain and its flanked N-and C-terminal domains. It excites the downstream signaling molecules through activation of coupling receptors and autophosphorylation,initiates corresponding cell signal transduction pathways,and ultimately results in a series of cellular morphological and functional changes. In this review,we reviewed the research of Pyk2 involving in cell signal transduction pathways so far in order to comprehensively understand the role of Pyk2 and provide new perspectives for diagnosis and treatment of related diseases.