人工泪液凝胶联合羟糖甘滴眼液对干眼症的疗效

Therapeutic effect of artificial tear gel combined with Hypromellose 2910,Dextran 70 and Glycerol Eye Drops on xerophthalmia

目的研究卡羟糖甘滴眼液联合人工泪液凝胶对干眼症患者的临床疗效。方法选取2016年3月~2017年5月我院收治的86例干眼症患者作为研究对象,根据治疗时间的先后将患者分为对照组(43例)和研究组(43例)。对照组采用卡波姆眼用凝胶治疗,研究组在对照组的基础上加用羟糖甘滴眼液,比较两组患者治疗后的泪膜破裂时间、泪液分泌时间、角膜荧光素染色评分以及治疗总有效率。结果研究组患者的临床治疗总有效率(95.35%)显著高于对照组(81.40%),差异有统计学意义(P<0.05);研究组患者的泪液分泌时间和泪膜破裂时间均长于对照组,且研究组的角膜染色评分低于对照组,差异有统计学意义(P<0.05)。结论在干眼症患者的治疗中,羟糖甘滴眼液与卡波姆眼用凝胶联用可以有效缓解患者的症状,疗效显著,应用价值高。

Objective To study the clinical effect of Hypromellose 2910,Dextran 70 and Glycerol Eye Drops combined with artificial tear gel on patients with xerophthalmia.Methods From March 2016 to May 2017,86 patients with dry eye treated in our hospital were enrolled as research objects.According to the successive sequence of treatment time,patients were divided into control group（n=43） and research group（n=43）.In the control group,Carbomer Eye Gel was used,while in the research group,on the basis of the control group,Hypromellose 2910,Dextran 70 and Glycerol Eye Drops was added.The tear film break-up time,tear secretion time,corneal fluorescein staining score as well as the total effectiveness rate between the two groups were compared.Results The total clinical effectiveness rate was 95.35% in the research group,significantly higher than that in the control group accounting for 81.40%,with a statistical difference（P〈0.05）.The tear secretion time and tear film break-up time were longer in the research group than those in the control group,and the corneal fluorescein staining score in the research group was lower than that in the control group,the difference was statistically significant（P〈0.05）.Conclusion In the treatment of patients with xerophthalmia,combination of Hypromellose 2910,Dextran 70 and Glycerol Eye Drops and Carbomer Eye Gel can effectively alleviate patient＇s symtoms in a remarkable effect and has a high application value.