环磷酰胺与泼尼松联合治疗特发性间质性肺炎的效果分析

Effect analysis of Cyclophosphamide and Prednisone in the treatment of idiopathic interstitial pneumonia

目的研究环磷酰胺与泼尼松联合治疗特发性间质性肺炎的临床效果。方法选取2015年2月~2016年9月我院收治的60例特发性间质性肺炎患者作为研究对象,根据收治时间先后顺序将其分为对照组和观察组,每组各30例。对照组患者采用泼尼松治疗,观察组患者在对照组治疗基础上联合环磷酰胺进行治疗。观察对比两组患者的治疗总有效率、不良反应发生率、肺功能指标、治疗前后睡眠质量评分及生活质量评分。结果观察组患者的治疗总有效率(96.67%)高于对照组(70.00%),不良反应发生率(6.67%)低于对照组(30.00%),各项肺功能指标(PEF、MVV、FVC)均高于对照组,差异有统计学意义(P<0.05)。治疗前,两组患者的睡眠质量评分及生活质量评分比较,差异无统计学意义(P>0.05)。治疗后,观察组患者的睡眠质量评分低于对照组,生活质量评分高于对照组,差异均有统计学意义(P<0.05)。结论环磷酰胺与泼尼松联合治疗特发性间质性肺炎的效果优于单纯使用泼尼松,可有效改善患者的肺功能指标及预后效果,具有较高的临床推广价值。

Objective To study the clinical efficacy of Cyclophosphamide and Prednisone in the treatment of idiopathic interstitial pneumonia.Methods Sixty patients with idiopathic interstitial pneumonia admitted in our hospital from February 2015 to September 2016 were selected as the study subjects.They were divided into control group and observation group according to the order of treatment time,with 30 cases in each group.In the control group,Prednisone alone was used,while in the observation group,on the basis of the control group,Cyclophosphamide was added.The total effectiveness rate,incidence of adverse reactions,pulmonary function indicators,sleeping quality score and quality of life score before and after treatment were observed and compared between the two groups.Results In the observation group,the total effectiveness rate was 96.67%,which was higher than that in the control group accounting for 70.00%,the incidence of adverse reactions was 6.67%,which was much lower than that in the control group accounting for 30.00%,the pulmonary function indexes（PEF,MVV,FVC） in the observation group were all higher than those in the control group,the differences were statistically significant（P〈0.05）.Before treatment,there was no significant difference in the scores of sleeping quality or quality of life between the two groups（P〉0.05）.After therapy,the score of sleeping quality in the observation group was lower than that in the control group,and the score of quality of life in the observation group was higher than that in the control group,the differences were statistically significant（P〈0.05）.Conclusion The combination of Cyclophosphamide and Prednisone in the treatment of idiopathic interstitial pneumonia is superior to the Prednisone treatment alone,which can effectively improve the pulmonary function indexes and patient′s prognosis with a high clinical value for promotion.