基于TGFβ1/BMP探讨血管平滑肌细胞增殖对肺动脉高压的影响

Effect of TGFβ1/BMP on pulmonary arterial hypertension induced by vascular smooth muscle cell proliferation

肺动脉高压(PAH)是肺血管破坏性疾病,具有致命性且预后较差的特点,目前尚不能完全治愈。该疾病的主要致病因素是肺动脉血管平滑肌介质的增厚和平滑肌细胞进入血管内膜的侵入性增殖。这种异常增殖导致脉管肥大,肺血管阻力和肺动脉压持续升高。且TGFβ_1/BMP信号通路是调节肺动脉高压的肺动脉血管重构的重要信号传导路径,通路中涉及的多个关键靶点成为药物研究、临床治疗或病理机制研究的常用靶点。因此,本文基于TGFβ_1/BMP信号通路,从血管平滑肌细胞增殖调控的角度对PAH的病理生理的影响及机制作一综述。

Pulmonary arterial hypertension（PAH） is a pulmonary vascular devastating disease.It has the characteristics of fatality and poor prognosis,and it is currently not completely curable.The main pathogenic factors of this disease are the thickening of the pulmonary vascular smooth muscle medium and the invasive proliferation of smooth muscle cells into the intima.This abnormal proliferation leads to vascular hypertrophy,pulmonary vascular resistance and pulmonary arterial pressure continue to rise.And TGFβ1/BMP signaling is an important signal transduction pathways regulating pulmonary arterial remodeling of pulmonary hypertension,which involved a number of key targets in drug research,clinical treatment and pathological mechanisms study.This review summarizes the effects of TGFβ1/BMP signaling pathway on PAH and its mechanism of the vascular smooth muscle cell proliferation.